探讨青年和绝经后女性乳癌c erbB 2、p53、ER、PR的表达及意义。方法 采用SP法检测青年组 (13 1例 )与绝经组 (13 6例 )乳癌组织中各指标的表达及其与临床分期、腋淋巴结 (ALN )转移、3年无病生存率 (DFS)之间的关系。结果 c erbB 2阳性与临床分期、ALN转移相关 (P <0 .0 5) ,c erbB 2阳性者 3年DFS低于阴性者 (P <0 .0 5)。青年组c erbB 2、p53阳性率高、ER阳性率低 (P <0 .0 1) ,3年DFS低于绝经组 (P <0 .0 5)。结论 c erbB 2表达是乳腺癌预后重要指标 ,青年乳腺癌c erbB 2、p53阳性率高 ,ER阳性率低 ,3年DFS低 ,预后较差。
To study the expression of c erbB 2?p53?ER and PR between young and postmenopausal women with breast cancer. Methods The expression of c erbB 2?p53?ER and PR in 131 young women and 136 Postmenopausal women with breast cancer were studied by S? P immunohistochemistry,with its relation with clinical TNM stage?axillary lymph node(ALN) metastasis and 3 year disease-free survival(DFS). Results The expression of c erbB 2 correlated with clinical TNM stages and ALN metastasis( P < 0.05 ...
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原文发布时间:2003/10/14
引用本文:
张英;刘永源;黄应桂.青年和绝经后女性乳腺癌c-erbB-2、p53、ER和PR受体表达及意义.http://ynau.firstlight.cn/View.aspx?infoid=3330851&cb=hangxiaojingxg.
发布时间:2003/10/14.检索时间:2024/12/13