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Effects of chronic alcohol treatment on the synthesis, sialylation, and disposition of nascent apolipoprotein E by peritoneal macrophages of rats
Chronic ethanol feeding macrophages apolipoprotein E glycosylation sialylation sialic acid content
2016/6/7
Background: Plasma apolipoprotein (apo) E, a sialoprotein,
plays an important role in reverse cholesterol transport. Previously,
we showed that chronic alcohol consumption impairs glycosylation
of ...
Oral bioavailability and intestinal disposition of dehydroandrographolide in rats
脱水穿心莲内酯 药代动力学 肠道处置 Caco-2细胞 大鼠在体肠灌流
2012/8/20
目的研究脱水穿心莲内酯在大鼠体内的口服生物利用度和肠道处置，为其在临床的使用和开发提供有用的信息。方法研究脱水穿心莲内酯在大鼠体内的药代动力学行为。采用Caco-2细胞模型和大鼠在体肠灌流模型研究脱水穿心莲内酯在大鼠体内的肠道处置。结果脱水穿心莲内酯的口服绝对生物利用度是11.92%。在Caco-2细胞模型中，脱水穿心莲内酯从基底膜到顶端膜方向转运的表观渗透系数（5.37×10-5 cm/s）约等...
Drug-Metabolizing Enzymes and Transporters：Expression in the Human Prostate and Roles in Prostate Drug Disposition
Drug-Metabolizing Enzymes Transporters Human Prostate Prostate Drug Disposition
2008/12/23
Local biotransformation enzymes and transporter proteins in tissues may exert a profound effect on drug pharmacokinetics in those tissues. Thus, the use of drugs for the treatment of benign prostatic ...
Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm
MINMOD glucose regulation simulation algorithm
2010/2/26
The degree of freedom (DOF) of MINMOD was found to be 7. The model was maximally simplified in the dimensionless formulation that normalizes the variation in glucose and insulin during FSIVGTT. In the...
Intercultural Disposition and Communication Competence of Future Pharmacists
intercultural disposition intercultural competence cultural sensitivity communication
2018/3/28
Objective. To determine the influence of an educational intervention on pharmacy students' intercultural disposition and perceived communication competence.
Methods. The relationship between intercul...
Disposition of Alpha-1-Antitrypsin in the Isolate Perfused Rabbit Lung
Alpha-1-Proteinase Inhibitor Pulmonary absorption Isolated perfused rabbit lung
2010/4/29
The potential for delivering large molecular weight proteins into the lungs to reach local or systemic sites of action was investigated by examining the disposition of alpha-1-antitrypsin in the isola...