搜索结果: 1-15 共查到“知识库 理学 HBV”相关记录23条 . 查询时间(0.109 秒)
Protein & Cell：许敏/代绍兴/左大明/袁硕峰合作揭示hnRNPA2B1的首个激动剂PAC5抗HBV和SARS-CoV-2体内活性的新机制（图）
乙型肝炎病毒 病毒性疾病 蛋白酶 核传感器
2022/9/15
新发和反复爆发的病毒性疾病是一个严重的公共卫生问题。历史上，乙型肝炎病毒 (HBV) 已夺去数百万人的生命。目前，COVID-19大流行已造成巨大的经济损失和数百万人死亡。乙型肝炎是一种慢性病毒性疾病，其主要挑战是消除HBV共价闭合环状DNA (cccDNA)，减少乙型肝炎表面抗原 (HBsAg)。
化学合成多肽体外抗HBV复制的研究
化学合成多肽 乙型肝炎病毒 HBV-DNA复制 拉米夫定
2020/6/1
观察人工设计并化学合成的多肽在体外乙型肝炎病毒（HBV）复制模型中对HBV-DNA复制、病毒标志物表达的影响，及其细胞毒性强弱，筛选高HBV抑制且低细胞毒性的多肽，探索多肽作为新型HBV抗病毒药物分子的潜力。方法 采用传统的甲基丙烯酸聚合物平台设计并合成的7种多肽（KBDT-1、2、3……7，以疏水性及阳离子电亲和力大小为依据），将7种化学合成多肽（10 mg/mL）、拉米夫定（1 mg/mL，阳...
分析HbeAg阴性与阳性慢性乙肝合并肝硬化患者血清乙型肝炎病毒(HBV)-DNA载量与肝脏生化指标的相关性。方法 回顾性分析煤炭总医院消化内科2015年1月至2017年1月期间收治的95例慢性乙肝合并肝硬化患者的临床资料，所有患者入院后均完善乙肝两对半检查，根据患者乙型肝炎 e抗原(HbeAg)携带情况将其分为阳性组51例和阴性组44例。患者入院检查时均完善HBV-DNA载量及肝脏功能等生化检查，...
THE DEVELOPMENT OF A SNOW ROUTINE FOR THE HBV-2 MODEL
DEVELOPMENT SNOW ROUTINE HBV-2 MODEL
2009/10/29
The development of a snow routine for the HBV-2 rainfall-runoff model
is described. Experiences from field investigation that have contributed to
the work are briefly discussed.
In the snow routine...
Development of a Process Oriented Calibration Scheme for the HBV Hydrological Model
Process Oriented Calibration Scheme HBV Hydrological Model
2009/10/26
A process oriented calibration scheme (POC), developed for the HBV hydrological
model is presented. Twelve parameters were calibrated in two steps.
Firstly, initial parameter estimates were made fro...
A Simple Automatic Calibration Routine for the HBV Model
Automatic Calibration Routine HBV Model
2009/10/23
A simple, but efficient, method for automatic calibration of the conceptual HBV
rainfall-runoff model was developed. A new criterion, which combines the com-
monly used efficiency criterion R 2 and ...
Estimation of Parameter Uncertainty in the HBV Model
Estimation of Parameter Uncertainty HBV Model
2009/10/23
Usually the HBV model is calibrated by seeking one optimal parameter set that
represents the catchment. From experience we know, however, that it is hardly
poss~ble to find an unique parameter set. ...
Priestley-Taylor Evapotranspiration in HBV-Simulations
Priestley-Taylor Evapotranspiration HBV-Simulations
2009/10/23
Estimations of potential evapotranspiration as input to runoff calculations with
the HBV model are usually given as monthly standard values calculated with the
Penman method. Daily changes in the we...
Internal HBV-96 Variables and Phosphorus Transport Processes
Internal HBV-96 Variables Phosphorus Transport Processes
2009/10/23
The high data requirements of total phosphorus (TP) transport prediction tools
limit their application. Recently, research has therefore started in Sweden to use
a conceptual hydrological model, HBV...
Nitrogen Concentrations Simulated with HBV-N:New Response Function and Calibration Strategy
Nitrogen Concentrations HBV-N New Response Function Calibration Strategy
2009/10/23
HBV-N is a conceptual process-based model for simulation of transformation
and transport of nitrogen on the catchment scale. This paper presents further development
with focus on the response functi...
An Energy Balance Based HBV- Model with Application to an Arctic Watershed on Svalbard,Spitsbergen
Energy Balance HBV- Model Arctic Watershed
2009/10/22
In several studies of snowmelt using the temperature index method from the original HBV-model, the model fails to predict the timing of the snowmelt and underestimates the intensities on occasions wit...
Technical Note：Updating procedure for flood forecasting with conceptual HBV-type models
flood forecasting conceptual HBV-type models rainfall-runoff model
2009/5/15
Flood forecasting is of increasing importance as it comes to an increasing variability in global and local climates. But rainfall-runoff models are far from being perfect. In order to achieve a better...
人乙型肝炎病毒(HBV)adr亚型基因组的多态性
HBVadr基因 限制性内切酶图谱 多形性
2007/12/24
摘要 由乙型肝炎adr亚型病毒(HBVadr)携带者26人的混合血清,得到了HBVadr基因组克隆株(PADR)158株,对这些克隆株进行四种限制性内切酶(BglⅡ,HindⅢ,PstⅠ,XhoⅠ)切点测定,并对其中S株的13种限制性内切酶图谱进行比较研究,发现同为adr亚型病毒,其基因组的限制性酶切图谱存在差异。另外,通过HindⅢ)切点得到的12个克隆株(PADR-H),也进行了酶切图谱分析。...
tRNA-包埋核酶在HepG2细胞中的抗HBV活性
乙型肝炎病毒(HBV) 核酶 tRNA-包埋核酶 HepG2细胞
2007/12/20
摘要 已知 ｔ Ｒ Ｎ Ａ包埋核酶比裸露核酶在胎牛血清和 Ｈｅｐ Ｇ２ 细胞抽提液中有较高的稳定性 构建了 ｈ Ｃ Ｍ Ｖ 启动子驱动下的抗 Ｈ Ｂ Ｖ（ａｄｒ 亚型）的 ｔ Ｒ Ｎ Ａ包埋核酶基因质粒，与携带 Ｈ Ｂ Ｖ 基因的ｐ１２Ⅱ质粒共转染 Ｈｅｐ Ｇ２ 细胞，用 Ｇ４１８ 筛选抗性细胞 分析稳定表达细胞中的 Ｈ Ｂ Ｖ Ｒ Ｎ Ａ， Ｈ Ｂ Ｖ 抗原合成和新生 Ｄ...
摘要 本文首次报告用3’—末端核苷酸转移酶将生物素—11—dUTP标记到人工合成的21寡核苷酸上,该d(NMP)_(21)与HBV DNA长链缺口区附近的序列互补,并含HBV DNA的直接重复序列(Direct Repeat)。本文对其标记条件、检出方法进行观察比较,找出合适的条件,制成的生物素化d(NMP)_(21)探针可与标准的HBVDNA进行杂交,检测敏感度为25pg。用这种探针可以从乙型肝...