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肢端型黑色素瘤（acral melanoma, AM）是一种起源于手掌、足底和甲下等部位的恶性皮肤肿瘤，也是亚洲人群中最主要的黑色素瘤亚型。原位AM（AM in situ, AMis）突破基底膜进入真皮发展为侵袭性AM（invasive AM, iAM）是造成患者预后变差的重要里程碑事件。然而，目前关于AMis的研究仍然十分有限，AMis向iAM的演化过程尚不清楚，免疫微环境在这一过程中发挥的作用...
肝癌是中国高发恶性肿瘤。由于其广泛的肿瘤异质性，最新的靶向联合免疫治疗的方案仅对20~30%的患者有效，并且缺乏指导精准用药的药敏分子分型。因此亟需研究可以指导肝癌精准用药的分子分型和揭示新的耐药靶点。
The Oncolytic Effect of Respiratory Syncytial Virus (RSV) in Human Skin Cancer Cell Line, A431
Oncolytic Viruses Apoptosis Skin Neoplasms Flow Cytometry
2015/9/29
Background: Oncolytic viruses have become of noticeable interest as a novel biological approach for selectively infecting cancer cells and triggering apoptosis in a number of malignant cells. Many res...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
Effects of Phytochemicals from Rhodiola crenulata on Highly Invasive Breast Cancer Cell Lines and Embryonic Models of Migration
Cancer Mammary Metabolism Metastasis Natural Product Rhodiola crenulata
2014/12/10
The root of the Tibetan plant Rhodiola crenulata is part of eastern traditional medicine. Studies have suggested that members of the Rhodiola genus display anticancer properties. In this study we exam...
In Vitro Characterization of Docetaxel as a Radiosensitizer in Canine and Feline Cancer Cell Lines
Docetaxel Chemotherapy Radiation Therapy In Vitro
2013/2/19
An In Vitro study was conducted to investigate docetaxel as a radiation sensitizer in four canine (mammary carcinoma—CMT12 and CMT25, osteosarcoma—OS2.4, and transitional cell carcinoma—PTCC), and one...
Apoptosis Induced by N-Nitrosamines in Two Cancer Cell Lines
N-nitrosopyrrolidine N-nitrosodimethylamine Apoptosis Caspases HL-60 Cells HepG2 Cells
2013/3/13
In the present study, we investigated the induction of apoptosis by N-nitrosopyrrolidine (NPYR) and N-nitrosodimethy-lamine (NDMA) in two human cell lines: HL-60 (leukemia) and HepG2 (hepatoma). Apopt...
The death receptor TRAIL in cancer cell apoptosis
Death receptor Fas TNF-α TRAIL cancer apoptosis
2009/7/15
Apoptosis is a key regulator or tissue homeostasis. Death ligands and death receptors of the tumor necrosis factor (TNF) family play crucial roles in mediating apoptosis. TNF-related apoptosis-inducin...
Arsenic Trioxide Has Additive Cytotoxic Effects on MCF-7 Breast Cancer Cell Line With Taxanes
breast cancer MCF-7 arsenic trioxide docetaxel paclitaxel
2009/6/25
Breast cancer is the most prevalent cancer in women and an important cause of both morbidity and mortality. Although long-term disease-free survival is offered to women with early stage disease by cur...
Statistical models to study subtoxic concentrations for some standard mutagens in three colon cancer cell lines
Inverse regression problem subtoxic concentration confidence interval
2009/2/23
The aim of this work is to propose models to study the toxic effect of different concentrations of some standard mutagens in different colon cancer cell lines. We find estimates and, by means of an in...