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二甲双胍作为最常用的降糖药物，已经被报道在多种肿瘤中可作为潜在的抗肿瘤药物。然而，由于二甲双胍的具体作用靶点不明确，极大地限制了我们对二甲双胍的理解和应用，并且二甲双胍在不同亚型的肿瘤中疗效并不相同。
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Fusion mechanism 2019-nCoV inhibitors targeting HR1 domain spike protein
2020/6/12
Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for th...
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women
aging appetite and energy intake gastrointestinal function gastrointestinal mechanisms sex whey protein
2018/11/19
Background: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestin...
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women
aging appetite and energy intake gastrointestinal function gastrointestinal mechanisms sex whey protein
2018/11/16
Background: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestin...
Association of dietary protein and dairy intakes and change in renal function: results from the population-based longitudinal Doetinchem cohort study
dairy dietary proteins general population longitudinal study renal function
2018/12/19
Background: Evidence has suggested that protein from dairy may be less detrimental to renal health than protein from nondairy products. However, to our knowledge, no previous studies have used cystati...
Growth of infants consuming whey-predominant term infant formulas with a protein content of 1.8 g/100 kcal: a multicenter pooled analysis of individual participant data
multicenter individual participant data pooled analysis low-protein infant formula breast milk infant growth probiotics prebiotics
2018/12/14
Background: High protein intake during infancy may contribute to obesity later in life in infants who are not exclusively breastfed. Lowering the protein content of infant formula so it is closer to t...
Growth of infants consuming whey-predominant term infant formulas with a protein content of 1.8 g/100 kcal: a multicenter pooled analysis of individual participant data
multicenter individual participant data pooled analysis low-protein infant formula breast milk infant growth probiotics prebiotics
2018/12/18
Background: High protein intake during infancy may contribute to obesity later in life in infants who are not exclusively breastfed. Lowering the protein content of infant formula so it is closer to t...
Reformulating cereal bars: high resistant starch reduces in vitro digestibility but not in vivo glucose or insulin response; whey protein reduces glucose but disproportionately increases insulin
randomized clinical trial blood glucose humans insulinemic response postprandial glycemic response
2018/12/14
Background: Resistant starch (RS) and whey protein are thought to be effective nutrients for reducing glycemic responses.
Maternal protein intake during pregnancy and linear growth in the offspring
linear growth pregnancy protein cohort maternal diet programming
2018/12/18
Background: Observational and experimental evidence demonstrates that protein intake in infancy programs linear growth. To our knowledge, few studies have examined prenatal maternal protein intake.
Reformulating cereal bars: high resistant starch reduces in vitro digestibility but not in vivo glucose or insulin response; whey protein reduces glucose but disproportionately increases insulin
randomized clinical trial blood glucose humans insulinemic response postprandial glycemic response
2018/12/18
Background: Resistant starch (RS) and whey protein are thought to be effective nutrients for reducing glycemic responses.
Diets higher in animal and plant protein are associated with lower adiposity and do not impair kidney function in US adults
higher-protein diet kidney function cardiometabolic risk NHANES protein source central adiposity
2018/12/14
Background: Higher-protein diets are associated with decreased adiposity and greater HDL cholesterol than lower protein diets. Whether these benefits can be attributed to a specific protein source (i....