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Generalized Likelihood Ratio Statistics and Uncertainty Adjustments in Efficient Adaptive Design of Clinical Trials
Hoeffding’s information bound Internal pilot Kullback-Leibler information Modified Haybittle-Peto test Multiparameter exponential family Sample size re-estimation
2011/6/20
A new approach to adaptive design of clinical trials is proposed in a general multi-
parameter exponential family setting, based on generalized likelihood ratio statistics and optimal
sequential tes...
Efficient adaptive designs with mid-course sample size adjustment in clinical trials
adaptive design conditional power futility Kullback-Leibler information sample size re-estimation
2011/6/17
Adaptive designs have been proposed for clinical trials in which the nuisance parameters
or alternative of interest are unknown or likely to be misspecified before the trial. Whereas most
previous w...
Handling Covariates in the Design of Clinical Trials
Balance covariate-adaptive randomization covariate-adjusted response-adaptive randomization effi ciency ethics
2011/3/23
There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stratification and covar...
Handling Covariates in the Design of Clinical Trials
Balance covariate-adaptive randomization covariate-adjusted response-adaptive randomization effi ciency ethics
2011/3/22
There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stratification and covar...