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Graphene binds drugs which kill bacteria on medical implants
infection prevention graphene bactericidal molecules
2021/8/10
Bacterial infections relating to medical implants place a huge burden on healthcare and cause great suffering to patients worldwide. Now, researchers have developed a new method to prevent such infect...
New antimyeloma drugs in spinal cord infiltration for multiple myeloma. Determination of lenalidomide in cerebrospinal fluid with ultrasensitive high-performance liquid chromatography
Lenalidomide Multiple Myeloma Spinal Cord Infiltration
2013/1/30
A 64-year-old woman with IgA kappa multiple myeloma was treated with thalidomide-dexa- methasone. Due to progression of the disease, bortezomib, doxorubicin and dexamethasone were administered, follow...
In vitro effect of current antimalarial drugs on the survival of paired Schistosoma mansoni adult worms and their egg production
antischistosomal drugs antimalarial drugs Schistosoma mansoni
2010/12/10
Some field trials have already demonstrated the high antischistosomal potential of combination therapies using Artesunate (ART) and current antimalarial drugs (Boulanger et al., 2007; Mohamed et al., ...
Chiral Drugs. An Overview
Chiral Drugs Overview
2009/4/20
About more than half of the drugs currently in use are chiral compounds and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. Although the...
Overview of Major Classes of Plant-Derived Anticancer Drugs
EGCG thymoquinone paclitaxel pomiferin sulforaphane cancer
2009/4/8
Cancer is the second leading cause of death worldwide. Conventional cancer therapies cause serious side effects and, at best, merely extend the patient’s lifespan by a few years. Cancer control may th...
Induction of cell cycle arrest and apoptosis in JAR trophoblast by antimalarial drugs
cell cycle arrest apoptosis JAR trophoblast antimalarial drugs
2009/3/2
Chloroquine, quinine, artemisinin, and pyrimethamine are generally considered safe drugs for treatment of malaria during pregnancy; however, high doses of these drugs are detrimental with adverse ou...
Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts
Ischemia reperfusion dysfunction model-estimated kinetics myofilament interaction inotropic drugs
2010/2/26
We found that IR injury resulted in reduced myofilament Ca2+ sensitivity, and decreased cross-bridge association and dissociation rates. Dopamine (8 μM) reduced myofilament Ca2+ sensitivity before, bu...
MEMBRANE POTENTIAL CHANGE EFFECTS ON CATIONIC AND NEUTRAL DRUG - INDUCED ERYTHROCYTE SHAPE CHANGE AND CELLULAR UPTAKE OF DRUGS.
Membrane potential cationic drugs drug uptake
2009/12/17
The effect of membrane potential change of the human erythrocytes on cationic drugs tetracaine and chlorpromazine and neutral drug benzyl alcohol induced cell shape change and red cell uptake of drug ...