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A New Biomarker for Hepatocellular Damage: Plasma Cell-Free DNA
Hepatocellular Damage Cell-Free DNA
2013/1/28
Background: Accumulating evidence has suggested that cell-free DNA (cf-DNA) enters the circulation following cell apoptosis or necrosis. An increased level of cf-DNA fragments has been found in the bl...
Type 2a sodium-phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidneys of septic mice
renal dysfunction tubular apical damage
2009/12/16
Acute renal failure (ARF) occurs in septic patients and is histologically characterized by tubular apical damages, including brush border breakdown. Nevertheless, little information is available to id...
Genetic Studies of Bone Diseases: Evidence for Involvement of DNA Damage Response Proteins in Bone Remodeling
p53 Atm c-Abl osterix osteoblast osteoporosis
2009/4/20
Bone remodeling is carried out by bone marrow mesenchymal stem cell derived osteoblasts, which form the bones, and hematopoeitic stem cell derived osteoclasts, which absorb the bones. Their actions a...
Construction of HeLa cell lines overexpressing metallothioneins-1 and -2 and their cytoprotective effects against oxidative damage induced by hydrogen peroxide
cell viability copper cytoprotective effect HeLa cell metallothionein
2009/4/1
It has been suggested that metallothioneins (MTs) play a role to protect cells from toxic effects of oxidative stress and heavy metals. On the other hand, the ability of Cu-containing MT to protect ce...
Localization of oxidative DNA damage after Au injection and effects of Au on Cp in renal kidney
Gold (Au) Copper (Cu) Ceruloplasmin (Cp) 8-hydroxydeoxyguanosine (8-OHdG) Metallotionein (MT)
2009/4/1
The present study was carried out to investigate the effect of gold (Au) injection on copper (Cu) and two types of ceruloplasmin (Cp), total Cp (ID1) and active Cp (ID2), metallothionein (MT) in the s...
Oxidative damage of prion protein induced by reactive oxygen species
Oxidative damage prion protein induced reactive oxygen species
2009/4/1
Prion protein (PrP) consists of an amino-terminal domain containing a series of octapeptide repeats with the consensus sequence PHGGGWGQ and a carboxyl-terminal domain composed of three α-helices and ...
Mechanisms of the DNA Damage in Rat Kidney after Au Injection
Gold (Au) Copper (Cu) 8-hydroxydeoxyguanosine (8-OHdG) DNA damage Metallothionein (MT)
2009/3/16
Au (gold) is a heavy metal and its complexes are one of the more effective medicaments available for rheumatoid arthritis, although many authors have reported serious kidney damage during the chrysoth...
Acute Harmful Effects after Single Intravenous Dose of Cadmium Fluoride in Rats(First report)-Lethal dose, severe hepatic damage, renal injury, abnormal serum electrolytes and metabolic acidosis-
cadmium fluoride intravenous injection acute lethal toxicity liver and renal dysfunction
2009/3/16
Acute Harmful Effects after Single Intravenous Dose of Cadmium Fluoride in Rats(First report)-Lethal dose, severe hepatic damage, renal injury, abnormal serum electrolytes and metabolic acidosis.
Interferon-gamma liniment protects hairless mice against ultraviolet irradiation-induced skin damage
Interferon-gamma liniment protects hairless mice ultraviolet irradiation-induced skin damage
2009/3/3
Ultraviolet B (UVB) irradiation has been reported as one of causes of epidermal carcinoma and also one of immunosuppressive inducers associated with an up-regulated production of T helper (Th) 2-typ...
Analysis of mucin composition in gastric juices of chronic rheumatic patients with upper gastrointestinal damage
mucin composition gastric juices chronic rheumatic patients upper gastrointestinal damage
2009/3/3
Assessment of the mucin subclasses in the gastric juices of severe chronic rheumatoid arthritis (RA) patients was compared with non-RA cases which received the eradication treatment of Helicobacter ...