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Brca2 C-terminus interacts with Rad51 and contributes to nuclear focus formation in double-strand break repair of DNA
Brca2 C-terminus interacts Rad51 double-strand break repair of DNA
2009/3/3
In humans and mice, the interaction between the breast cancer susceptibility protein, BRCA2, and RAD51 recombinase is essential for DNA repair by homologous recombination, the failure of this process ...
Insertion/deletion polymorphism in the BRCA2 nuclear localization signal
Insertion/deletion polymorphism BRCA2 nuclear localization signal
2009/3/2
Mutations in human BRCA2 confer an increased risk of female breast cancer. In this study, we found a novel insertion/deletion polymorphism (10204insAAA causing amino acid change M3332IK) in canine B...