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Experiments were performed to determine whether the rat epididymis secretes a "forward-motility" factor(s) similar to that found by others in the bovine epididymis. Lumen content of the rat caput ...
We have previously reported that incubation of testicular slices with inhibin in the presence of 6 x 10-8 M oFSH resulted in a dose-related reduction in accumulation of cyclic AMP due to a decreas...
This study examined the potential role of testicular opioids, a pertussis toxin (PT)-sensitive G-protein, and phosphodiesterase in mediating the inhibitory effect of immobilization stress on testi...
Capacitation is the series of transformations that spermatozoa undergo in the female genital tract in order to bind to the zona pellucida, initiate the acrosome reaction, and fertilize an egg. Cyc...
The key to successful treatment of any condition is to understand and treat its causes. The same is true for erectile dysfunction (ED). In the past several decades, the causes of ED have been elucidat...
Phosphodiesterases (PDEs) are enzymes that degrade cyclic nucleotides. The calcium-calmodulin dependent PDE type 1 (PDE 1) and the cyclic adenosine monophosphate (cAMP)-specific PDE type 4 (PDE 4) h...

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