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Allergen Immunotherapy in Asthma: Current Status and Future Perspectives
allergic asthma allergic conjunctivitis allergic rhinitis immunotherapy Th2 responses
2010/11/12
Allergen immunotherapy targets Th2 cells activated by specific allergens, which constitutes the basis of allergic disease. Therefore, this approach has therapeutic potential for a variety of allergic ...
Hev b 6.02 Is the Most Important Allergen in Health Care Workers Sensitized Occupationally by Natural Rubber Latex Gloves
allergen health care workers latex allergy latex gloves skin prick test
2010/11/16
Background: Natural rubber latex (NRL) allergy is a common occupational disease in health care workers (HCW). However, few reports have compared the major allergen of HCWs to those in gloves that are ...
Effect of Antihistamine Eye Drops on the Conjunctival Provocation Test with Japanese Cedar Pollen Allergen
allergen provocation test allergic conjunctivitis antihistamine eye drops Japanese cedar pollinosis ketotifen fumarate levocabastine hydrochloride
2010/11/19
Preadministration of antihistamine eye drops suppressed the symptoms induced by the allergen, which suggests that this is an effective early therapy for Japanese cedar pollinosis, if it is started bef...
Efficacy of Levocabastine Hydrochloride Ophthalmic Suspension in the Conjunctival Allergen Challenge Test in Japanese Subjects with Seasonal Allergic Conjunctivitis
allergen challenge test allergic conjunctivitis conjunctival itching levocabastine hydrochloride redness
2010/11/18
The mean itching score in the levocabastine-treated group was 0.08 ± 0.06, which was significantly lower than the mean score of 1.98 ± 0.16 in the vehicle group (P < 0.0001). The redness and chemosis...
Role of the LTB4/BLT1 Pathway in Allergen-induced Airway Hyperresponsiveness and Inflammation
airway responsiveness cytokines lipid mediators lung inflammation Tcells
2010/11/18
LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory dis...
Interleukin-4 is involved in allergen-induced airway eosinophilic inflammation and bronchial hyperresponsiveness independent of genetic background
bronchial hyperresponsiveness eosinophils IgE interleukin-4 mice
2010/11/26
The role of interleukin (IL)-4 in the development of allergen-induced airway inflammation and bronchial hyperresponsiveness (BHR) is still controversial. To investigate the role of IL-4 in the develop...
Purification of a novel allergen (SAP-1), which induces allergic asthma, from the red soft coral (Alcyonium gracillimum)
allergic protein bronchial asthma IgE occupational allergy purification red soft coral
2010/11/26
The red soft coral that is found around the spiny lobster represents a major allergen and many fishermen, especially those that catch the spiny lobster, suffer from allergic symptoms. Therefore, in th...
Allergen immunotherapy: Current and new therapeutic strategies
allergen IgE immunotherapy T cell
2010/11/24
Allergen-specific immunotherapy (SIT) involves the administration of gradually increasing amounts of an allergen extract to reduce clinical symptoms of allergy. Well-controlled clinical trials have de...
Effect of cysteine mutagenesis on human IgE reactivity of recombinant forms of the major rye grass pollen allergen Lol p 1
allergy grass pollen Lol p 1 mutagenesis rye grass
2010/11/24
Background: Hypersensitivity to the group 1 grass pollen allergens is a significant causative factor in the onset of symptoms for hay fever sufferers. To better understand the IgE reactivity of the gr...
A Photo-immobilized Allergen Microarray for Screening of Allergen-specific IgE
allergen microarray allergen-specific IgE allergy diagnosis chemiluminescence photo-immobilization
2010/11/22
Background: We developed an in vitro system to diagnose allergy using an allergen microarray and photo-immobilization technique. Photo-immobilization is useful for preparing the allergen microarray be...
Increased expression of α4β7 integrin on food allergen-stimulated CD4+ T cells in active food allergic enterocolitis
α4β7 integrin αs-casein cow's milk allergy enterocolitis flow cytometry T cell
2010/11/29
We used flow cytometry to investigate the expression of α4β7 integrin on peripheral blood CD4+ T cells stimulated with αs-casein, one of the major allergens in milk allergy, in patients with milk-indu...