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A largescale new study provides further evidence that being overweight causes depression and lowers wellbeing and indicates both social and physical factors may play a role in the effect. With one in ...
探讨心血管病高危人群中医体质分布特点及与体质指数(BMI)、血脂的相关性。方法选取2017年4月—2017年5月在濮阳市华龙区社区服务中心进行筛查的心血管病高危人群421例,统计其中医体质分布情况及BMI、血脂等相关指标。采用中医体质辨识评分表进行体质量化评分,判断病人的中医体质类型,分析各中医体质与BMI、血脂的关系。结果421例高危病人中,偏颇体质360例,平和质61例;其中单纯偏颇体质以湿热...
原癌基因B细胞特异性小鼠白血病病毒插入位点1(BMI-1)为多梳基因家族的一员,是一种原癌基因,今年来有研究发现BMI-1基因与多种肿瘤发生、增值、转移和复发密切相关。本文介绍BMI-1的结构及生物学功能,综述其在膀胱癌、前列腺癌、肾癌肿瘤侵袭、转移中的作用及其相关机制。
探讨低切应力(LSS)对人脐静脉内皮细胞(HUVEC)中Bmi-1表达的影响及其可能的机制。 方法 原代培养HUVEC,免疫荧光检测Bmi-1在细胞中的定位;运用平行平板流动腔系统,给HUVEC加载0.5 Pa低切应力0.5 h、1 h、2 h和4 h,以无切应力加载为对照组,用实时定量RT-PCR检测Bmi-1 mRNA表达,用Western blot检测Bmi-1蛋白表达,利用p38特异性抑制...
Background: Pregnancy weight-gain z score charts have recently been proposed as a new tool for classifying gestational weight gain and establishing the link between weight gain and adverse maternal an...
Body Mass Index (BMI) has often questionably been used to define body build. In the present study body build was defined more specifically using fat free mass index (FFMI = fat free mass normalised to...
Background: With the increasing focus on obesity, growth patterns in infancy and early childhood have gained much attention. Although the adiposity rebound has been in focus because of a shown associa...
Background: Maternal obesity and weight gain during pregnancy are risk factors for child obesity. Associations may be attributable to causal effects of the intrauterine environment or genetic and post...
Background: With the increasing focus on obesity, growth patterns in infancy and early childhood have gained much attention. Although the adiposity rebound has been in focus because of a shown associa...
Background: Maternal obesity and weight gain during pregnancy are risk factors for child obesity. Associations may be attributable to causal effects of the intrauterine environment or genetic and post...
研究稳定期重度慢性阻塞性肺病(COPD) 患者中肌肉抑制素、动脉氧分压及二氧化碳分压的情况及相关性,并据BMI 进行分层研究。方法:选择稳定期重度COPD 男性患者为研究组及年龄相仿的中度COPD 男性为对照组,肺功能仪器检测每位受试者的1 s 用力呼气容积(FEV1) 及其预计值;测定身高及体质量,计算BMI,用酶联免疫吸附法测定肌肉抑制素;抽动脉血进行血气分析。研究组与对照组比较,探讨肌肉抑制...
Proximal femoral fracture (PFF) is one of the most important etiologies of mortality and morbidity in elderly. Reported mortality rate is in a range of 1.3 - 16% pre-operatively up to 22 - 42% postope...
Obesity is a prominent health problem among adults and children (20). In one longitudinal study, obesity at 10 yr of age strongly predicted obesity in adulthood (21); thus, preventing childhood obesit...
目的: 探索干扰Bmi-1基因后对其可能的下游基因Akt/PKB活性和P16INK4a基因表达的影响及对肿瘤细胞增殖和细胞衰老的作用. 方法: 用siRNA技术干扰Bmi-1表达后, 运用Western blot检测Bmi-1蛋白及相关蛋白pAkt、Akt和P16INK4a的表达, 同时进行SA-beta-Gal染色检测细胞衰老, 软琼脂克隆形成实验检测细胞的增殖能力. 结果: 转染Bmi-1 i...
探讨人类Blymphoma Mo-MLVinsertion region(Bmi-1)基因及其编码蛋白在骨髓增生异常综合征(myelodysplasia syndrome,MDS)发病中的地位和作用。方法以正常骨髓和白血病细胞系K562为对照,利用半定量RT-PCR和Western Blot研究MDS细胞系SKM-1中Bmi-1基因在mRNA和蛋白水平的改变。结果SKM-1中Bmi-1在mRNA和...

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