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Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia
rodent modeling and remodeling osteoblast
2014/12/4
Recent studies demonstrate that bisphosphonates suppress bone resorption by leading to apoptosis of the osteoclast and inhibiting the differentiation to mature osteoclasts. The influence of bisphospho...
Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone
basic multicellular unit alendronate
2014/12/4
Bisphosphonates (BPs) slow bone loss by reducing initiation of new basic multicellular units (BMUs). Whether or not BPs simply prevent osteoclasts from initiating new BMUs that resorb bone or also red...
CONTRIBUTION OF RANKL REGULATION TO BONE RESORPTION INDUCED BY PTH RECEPTOR ACTIVATION IN OSTEOCYTES
RANKL REGULATION CONTRIBUTION
2015/5/21
PTH increases osteoclasts by upregulating RANKL in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell remains undefined. Recent findings demonstrate that P...
Effect of Demineralized Bone Matrix on Resorption of Autogenous Cortical Bone Graft in Rats
Demineralized bone matrix autogenous graft bone resorption
2009/6/22
The purpose of this study was to evaluate the effect of demineralized bone matrix (DBM) on autogenous cortical bone resorption in rats. Fifty-six male Wistar rats were used and divided into the baseli...