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Princeton University researchers have found that dopamine – a brain chemical involved in learning, motivation and many other functions – also has a direct role in representing or encoding movemen...
For decades, scientists have struggled to develop a comprehensive census of cell types in the brain. Now, in a pair of companion papers, researchers at Columbia’s Mortimer B. Zuckerman Mind Brain Beha...
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathol...
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that has proven to be an important signaling molecule both as an extracellular primary messenger and as an intracellular second messenger. Ext...
Although paclitaxel is a commonly used anti-neoplastic agent for the treatment of solid tumors, therapy often results in a number of side effects, the most debilitating of which is peripheral neuropat...
A research team at UC San Francisco has discovered an RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells.The research, led by neurosurgeon...
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
A University of Queensland study has identified precisely when new neurons become important for learning.Lead researcher Dr Jana Vukovic from UQ’s Queensland Brain Institute (QBI) said the study highl...
The relationship between neurons of the thalamic reticular nucleus (TRN) and relay neurons of the thalamic nuclei was studied. Activation of the TRN neurons was shown to abate activity of relay neuron...
Background: The role of nucleus tractus solitarius in cardiovascular system regulation is controversial. On the other hand, study on the problem of hypertension in diabetic animals is the subject of m...
In the striatum, large aspiny (LA) interneurons survive transient cerebral ischemia while medium spiny (MS) neurons die. Excitotoxicity is believed to be the major cause for neuronal death after ische...
Autoactive neurons in the central nervous system of Helix and Aplysia were studied after exposure to several volatile anesthetics and under compression by mineral oil. Voltage clamp studies reveal tha...
This study was undertaken to examine the laminar distribution of spinotelencephalic tract neurons in the rat, by means of retrograde fluorescent labelling and to estimate the role of NADPH-diaphorase-...
NADPH-d reaction was performed on nine male Sprague-Dawley rats and morphometry of NADPH-d(+) cells was investigated in caudate-putamen, globus pallidus and ventral pallidum. In caudate-putamen we obs...
Breathing high levels of oxygen (i.e. hyperoxia) causes hyperventilation and unstable breathing in normal and carotid-deafferented animals (1,2). Prolonged exposure to hyperoxia can disrupt central ne...

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