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Dopamine neurons have a role in movement,new study finds(Nature Neuroscience)
Dopamine neurons movement
2016/5/6
Princeton University researchers have found that dopamine – a brain chemical involved in learning, motivation and many other functions – also has a direct role in representing or encoding movemen...
For decades, scientists have struggled to develop a comprehensive census of cell types in the brain. Now, in a pair of companion papers, researchers at Columbia’s Mortimer B. Zuckerman Mind Brain Beha...
Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons
NMDA receptor BDNF neurotrophins
2015/7/28
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathol...
Sphingosine 1-phosphate enhances excitability of sensory neurons through sphingosine 1-phosphate receptors 1 and/or 3
sphingosine 1-phosphate S1P excitability sensory neurons G protein-coupled receptors
2015/5/21
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that has proven to be an important signaling molecule both as an extracellular primary messenger and as an intracellular second messenger. Ext...
Paclitaxel alters the function of the small diameter sensory neurons
Small diameter sensory neurons paclitaxel vasodilatation
2015/5/21
Although paclitaxel is a commonly used anti-neoplastic agent for the treatment of solid tumors, therapy often results in a number of side effects, the most debilitating of which is peripheral neuropat...
UCSF Team Finds Key to Making Neurons From Stem Cells（图）
UCSF Team Making Neurons Stem Cells
2015/3/25
A research team at UC San Francisco has discovered an RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells.The research, led by neurosurgeon...
Implications of Ape1 in reactive oxygen signaling response following cisplatin treatment of dorsal root ganglion neurons
ROS APE1 base excision repair neurotoxicity
2014/12/12
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
A University of Queensland study has identified precisely when new neurons become important for learning.Lead researcher Dr Jana Vukovic from UQ’s Queensland Brain Institute (QBI) said the study highl...
Significance of the Thalamic Reticular Nucleus GABAergic Neurons in Normal and Pathological Activity of the Brain
Thalamic Reticular Nucleus Relay Neurons Seizure Activity Potentiation Cats
2013/1/29
The relationship between neurons of the thalamic reticular nucleus (TRN) and relay neurons of the thalamic nuclei was studied. Activation of the TRN neurons was shown to abate activity of relay neuron...
THE EFFECT OF HYPERGLYCEMIA ON NITRIC OXIDERGIC NEURONS IN NUCLEUS TRACTUS SOLITARIUS AND BLOOD PRESSURE REGULATION IN RATS WITH INDUCED DIABETES
Hyperglycemia Glutamate Sodium Nitroprusside Rat
2009/12/29
Background: The role of nucleus tractus solitarius in cardiovascular system regulation is controversial. On the other hand, study on the problem of hypertension in diabetic animals is the subject of m...
Inhibitory synpatic transmission in striatal neurons after transient cerebral ischemia
large aspiny neurons transient cerebral ischemia striatum
2015/5/21
In the striatum, large aspiny (LA) interneurons survive transient cerebral ischemia while medium spiny (MS) neurons die. Excitotoxicity is believed to be the major cause for neuronal death after ische...
Effect of interaction of volatile anesthetics and high hydrostatic pressure on central neurons
halothane elimination high hydrostatic pressure central neurons
2009/7/17
Autoactive neurons in the central nervous system of Helix and Aplysia were studied after exposure to several volatile anesthetics and under compression by mineral oil. Voltage clamp studies reveal tha...
Histochemical and Fluorescent Labelling of Neurons Projecting to Nucleus Accumbens:the Relation to Pain Processing
Nucleus accumbens Nociception Hyperalgesia NADPH-diaphorase Fluoro-Gold
2009/7/2
This study was undertaken to examine the laminar distribution of spinotelencephalic tract neurons in the rat, by means of retrograde fluorescent labelling and to estimate the role of NADPH-diaphorase-...
NADPH-Diaphorase-Reactive Neurons in Rat Basal Ganglia
caudate-putamen globus pallidus pallidum NADPH-diaphorase
2009/7/1
NADPH-d reaction was performed on nine male Sprague-Dawley rats and morphometry of NADPH-d(+) cells was investigated in caudate-putamen, globus pallidus and ventral pallidum. In caudate-putamen we obs...
Chemical oxidants acidify solitary complex (SC) neurons in the rat
Chloramines Animal rat Carbon Dioxide
2009/6/4
Breathing high levels of oxygen (i.e. hyperoxia) causes hyperventilation and unstable breathing in normal and carotid-deafferented animals (1,2). Prolonged exposure to hyperoxia can disrupt central ne...