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Nitric oxide (NO) is endogenously synthesized from L-arginine and L-citrulline. Due to its effects on nitric oxide synthase (NOS), reduced glutathione (GSH) may protect against the oxidative reduction...
Introduction: Tubular damage is common finding in acute renal failure (ARF). Various etiologies have been put forth to explain the tubular damage in ARF, one important mechanism among them is oxidativ...
Regular physical exercise beneficially influences cardiac antioxidant defenses in normal rats. The aim of this study was to test whether endurance training can strengthen glutathione-dependent antio...
Glutathione S-transferases (GSTs) play an important role in the detoxification of polycyclic aromatic hydrocarbons and aromatic amines, the toxic substances contained in cigarettes. GST Omega 1 (GSTO1...
Background: GST is a family of enzymes that are important in protection of the body against oxidative stress.
Objective To investigate the hypermethylation status of glutathione transferase P1(GSTP1) and E-cadherin (ECAD), TSGs (tumor suppressor genes) in our breast cancer samples and explore their correlatio...
The effects of dacarbazine, thiocolchicoside, methotrexate, olanzapine, pantoprazole sodium, and 5-fluorouracil on the enzyme activity of glutathione reductase (GR) were studied using human erythrocyt...
The changes in the serum sialic acid levels, total lipid peroxidation products (MDA), and glutathione reductase activity were estimated in patients with rheumatoid arthritis. Serum Sialic acid is know...
Two-dimensional electrophoresis (2-D electrophoresis) is a powerful and extensively used method for analysis of complex protein mixtures extracted from cells, tissue, or other biological samples such ...
In order to test the for existence of a possible effect during hemodialysis we investigated glutathione and related enzymes before and after dialysis of 36 patients (20 M/16 F) with chronic renal fail...
For most infectious diseases, increased formation of reactive oxygen species is secondary to the primary disease process. Some microorganisms are highly susceptible to exogenous reactive oxygen specie...
Cigarette smoke contains high concentrations of oxidants and reactive oxygen species. The aim of this study was to evaluate the effect of long-term cigarette smoking on glutathione (GSH) levels in bro...
Glutathione is an important thiol-containing compound involved in the detoxification process in erythrocytes. Its thiol group reacts with a variety of xenobiotics in a glutathione S-transferase cataly...
Sister chromatid exchange (SCE) and chromosomal aberration (CA) in peripheral lymphocytes have been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genoto...
Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat h...

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