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科学家发现DHA调节脑神经发育新机制
二十二碳六烯 神经元质膜 脑神经发育
2022/3/31
二十二碳六烯酸（DHA）是神经元质膜的重要组成部分。在大脑皮层灰质区，DHA主要存在于质膜磷脂，但同时也可在磷脂酶的作用下从膜上释放下来，以游离方式或通过其衍生物参与多种信号转导。
观察DHA对七氟烷诱导的小胶质细胞TLR4/MyD88/NFκB信号通路激活及炎症介质释放的影响。方法： N9小鼠小胶质细胞分为Con组、Sevo组和DHA+Sevo组，药物处理各组细胞24h后，采用MTT方法检测小胶质细胞存活率，采用western blot方法检测小胶质细胞TLR4、MyD88和IκB-α的表达量，检测各组培养基中炎症介质TNF-α、IL-1β和IL-6的含量。
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/14
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/18
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
DHA EPA inflammation men and women randomized controlled trial risk factors
2018/12/13
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight
birth weight DHA FADS long-chain PUFAs prenatal supplementation
2018/11/29
Background: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsatu...
Long-term effect of high-dose supplementation with DHA on visual function at school age in children born at <33 wk gestational age: results from a follow-up of a randomized controlled trial
docosahexaenoic acid DHA preterm infant very preterm visual processing
2018/11/26
Background: Children born preterm are at risk of visual-processing impairments. Several lines of evidence have contributed to the rationale that docosahexaenoic acid (DHA) supplementation of preterm i...
DHA- Rich Fish Oil Improves Complex Reaction Time in Female Elite Soccer Players
Fatty acids omega 3 efficiency decision-making
2015/5/7
Omega-3 fatty acids (n-3) has shown to improve neuromotor function. This study examined the effects of docosahexaenoic acid (DHA) on complex reaction time, precision and efficiency, in female elite so...
DHA对人肝癌细胞增殖与凋亡的影响及其机制的研究
癌 肝细胞 二十二碳六烯酸类 细胞凋亡
2014/5/11
探讨二十二碳六烯酸（DHA）对人肝癌细胞株Bel-7402增殖和凋亡的影响及其机制。方法：用不同浓度的DHA（0，25，50，100，200 μmol/L）分别作用人肝癌Bel-7402细胞24，48，72 h后，用MTT法检测细胞的增殖情况、Western blot检测Bcl-2和Bax蛋白的表达，并分别用流式细胞仪、real-time PCR和caspase-3活性检测试剂盒检测上述梯度浓度的...
初步探讨败血症患儿血标本分离的人苍白杆菌耐药机制。方法采用VITEK2 compact全自动微生物鉴定药敏系统对败血症患儿分离的病原菌进行鉴定和药敏试验；聚合酶链反应（PCR）法对人苍白杆菌受试株进行AmpC、AmpR、DHA1、AcrA、RamA、OprD、TEM、SHV等多重耐药基因检测，扩增产物经纯化后测序并进行序列分析。结果从败血症患儿的血标本中检出155株人苍白杆菌，从中随机选取30株...
孕期补充DHA能提高后代学习能力
孕期 DHA 后代 学习能力
2011/10/10
来自西安交通大学生命科学学院的研究人员经过大量的研究证实在怀孕期间补充DHA能够有效提高胎儿大脑海马中线粒体的活性，消除产前应激所产生的不良影响，最终有效提高后代学习与记忆能力。该项研究论文于2011年9月11日在线发表在自由基生物医学领域的权威期刊《抗氧化剂和氧化还原信号》（Antioxidants & Redox Signaling）上（影响因子8.2）。
DHA对脂多糖致小鼠急性肺损伤保护作用
二十二碳六烯酸 内毒素 急性肺损伤 氧化应激
2014/8/6
观察二十二碳六烯酸(DHA)预防脂多糖(LPS)性小鼠急性肺损伤(ALI)的效果,探讨其抗氧化作用机制。方法 雄性昆明种小鼠经灌胃给予DHA 250、500 mg/kg,连续10 d,然后经腹腔注射6 mg/kg脂多糖建立ALI模型;染毒16 h后,分别对各组动物肺组织进行病理学观察,支气管-肺泡灌洗液(BALF)和肺脏中氧化、抗氧化指标检测。结果 脂多糖明显损伤肺组织氧化和抗氧化系统,DHA能明...
美研究称补充DHA无助减缓老年认知障碍
DHA 老年认知障碍
2010/11/5
很多老年人都服用鱼油保健品，因为其中的主要成分之一DHA是一种对大脑十分重要的成分。但美国一项最新研究却认为，DHA无助于减缓老年轻度至中度认知障碍。