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中国科学技术大学课题组与合作者在《eLife》发文揭示SETD3蛋白作为β-actin组氨酸甲基化酶的结构与功能（图）
中国科学技术大学 SETD3蛋白 β-actin组氨酸 甲基化 酶
2019/2/27
近日，中国科学技术大学许超教授课题组与波兰华沙大学Jakub Drozak实验室合作，解析了SETD3与β-actin多肽的高分辨复合物晶体结构，并结合酶活实验揭示了肌动蛋白（Actin）第73位组氨酸（His73）的N3位甲基化的作用机制，相关成果以“Structural insights into SETD3-mediated histidine methylation on β-actin”...
In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane...
ADF/Cofilin Activation Regulates Actin Polymerization and Tension Development in Canine Tracheal Smooth Muscle
dissertations research thesis
2015/5/22
The contractile activation of airway smooth muscle tissues stimulates actin polymerization and the inhibition of actin polymerization inhibits tension development. Actin depolymerizing factor (ADF) an...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Regulation of the actin cytoskeleton in the pollen tube
Pollen tube ovule sperm plant sexual reproduction actin cytoskeleton protein
2014/12/11
Pollen tube growth, the process that transports the sperm cell to the ovule, is fundamental for plant sexual reproduction. The actin cytoskeleton is essential to the process of pollen tube elongation....
Analysis of the interaction between the epidermal growth factor receptor and actin
Epidermal growth factor protein amino acids growth factors actin cell free system cytosol cells actin immune
2014/12/11
It has been shown that the epidermal growth factor receptor (EGFR) can directly interact with F-actin via an actin-binding domain (ABD) located at amino acid residues 984–996. In this study, we invest...