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Inaugural J-WAFS Grand Challenge aims to develop enhanced crop variants and move them from lab to land（图）
J-WAFS 作物变种 基因工程
2023/6/5
According to MIT’s charter, established in 1861, part of the Institute’s mission is to advance the “development and practical application of science in connection with arts, agriculture, manufactures,...
Scientists report 6 novel variants in CRISPR-Cas12a in plants,expanding genome engineering（图）
report 6 novel variants CRISPR-Cas12a plants expanding genome engineering
2021/4/9
The research of plant scientist Yiping Qi at the University of Maryland focuses on innovative genome editing and engineering techniques in plants, with the goal of improving the efficiency o...
Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference
adiposity traits genetic variants interactions obesity soft drinks
2018/12/14
Background: Intake of sugar-sweetened beverages is associated with obesity, and this association may be modified by a genetic predisposition to obesity.
GFP Variants with Alternative β‑Strands and Their Application as Light-driven Protease Sensors:A Tale of Two Tails
Green Fluorescent Proteins Peptide Hydrolases Light
2016/5/25
Green fluorescent protein (GFP) variants that carry one extra strand 10 (s10) were created and characterized, and their possible applications were explored. These proteins can fold with either one or ...
Dynamic Stokes Shift in Green Fluorescent Protein Variants
GFP solvation response ultrafast
2016/5/25
Solvent reorganization around the excited state of a chromophore leads to an emission shift to longer wavelengths during the excited-state lifetime. This solvation response is absent in wild-type gree...
Green Fluorescent Protein Variants as Ratiometric Dual Emission pH Sensors.3.Temperature Dependence of Proton Transfer
Green Fluorescent Proteins Amino Acid Substitution Spectrometry, Fluorescence Kinetics Mutagenesis,Site-Directed Models,Theoretical Genetic Variation Hydrogen-Ion Concentration Thermodynamics Solvents
2016/5/24
In parts 1 and 2 of this series [Hanson, G. T., McAnaney, T. B., Park, E. S., Rendell, M. E. P., Yarbrough, D. K., Chu, S. Y., Xi, L. X., Boxer, S. G., Montrose, M. H., and Remington, S. J. (2002) Bio...
Green Fluorescent Protein Variants as Ratiometric Dual Emission pH Sensors.2.Excited-State Dynamics
Animals Protons Deuterium Luminescent Proteins Green Fluorescent Proteins Spectrometry, Fluorescence Biosensing Techniques Kinetics Genetic Variation Hydrogen-Ion Concentration
2016/5/24
In the preceding paper [Hanson, G. T., McAnaney, T. B., Park, E. S., Rendell, M. E. P., Yarbrough, D. K., Chu, S., Xi, L., Boxer, S. G., Montrose, M. H., and Remington, S. J. (2002) Biochemistry 41, 1...
Green Fluorescent Protein Variants as Ratiometric Dual Emission pH Sensors.1.Structural Characterization and Preliminary Application
Animals Cricetulus Cell Line Threonine Luminescent Proteins Green Fluorescent Proteins Microscopy, Confocal Crystallography, X-Ray Transfection Amino Acid Substitution
2016/5/24
Novel dual emission, pH-sensitive variants of the green fluorescent protein (GFP) have been constructed and are suitable for ratiometric emission measurements in vivo. This new class of GFPs, termed d...
Sugar-sweetened beverage intake, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics
gene-diet interaction Hispanics myocardial infarction sugar-sweetened beverage genetics
2018/11/29
Background: Chromosome 9p21 variants are among the most robust genetic markers for coronary artery disease (CAD), and previous studies have suggested that genetic effects of this locus might be modifi...
HUMAN CARBOXYLESTERASE 2 SPLICE VARIANTS: EXPRESSION, ACTIVITY, AND ROLE IN THE METABOLISM OF IRINOTECAN AND CAPECITABINE
Carboxylesterase alternative splicing colorectal cancer
2015/5/25
Carboxylesterases (CES) are enzymes that metabolize a wide variety of compounds including esters, thioesters, carbamates, and amides. In humans there are three known carboxylesterase genes CES1, CES2,...
Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer
Breast Cancer Tissue Microarray Splice Variant Gene Expression
2014/12/12
Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer.
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants
CLOCK circadian rhythm dietary intake gene-environment interaction sleep duration
2018/12/20
Background: Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor O...
Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3–fortified bread and milk during winter in Denmark
genetic polymorphism SNPs UVB radiation vitamin D status 25-hydroxyvitamin D vitamin D supplements
2018/12/20
Background: Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B–induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D ...
Identification of Exonic Nucleotide Variants of the Thyroid Hormone Responsive Protein Gene Associated with Carcass Traits and Fatty Acid Composition in Korean Cattle
Thyroid Hormone Responsive Protein (THRSP) Gene Unsaturated Fatty Acid SNP Beef Flavor Korean Cattle
2016/5/17
The thyroid hormone responsive protein (THRSP) gene is a functional gene that can be used to indicate the fatty acid compositions. This study investigates the relationships of exonic single nucleotide...
Using GWAS Data to Identify Copy Number Variants Contributing to Common Complex Diseases
Using GWAS Data Identify Copy Number Variants Contributing Common Complex Diseases
2010/11/16
Copy number variants (CNVs) account for more polymorphic base pairs in the human genome than do single nucleotide polymorphisms (SNPs). CNVs encompass genes as well as noncoding DNA, making these poly...