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When Yen-Jie Lee came to MIT as a graduate student in 2006, it was a bit of a culture shock. The aspiring particle physicist had studied physics at National Taiwan University before his career took a ...
Vibrational probes can provide a direct readout of the local electrostatic field in complex molecular environments, such as protein binding sites and enzyme active sites. This information provides an ...
Three different nitrile-containing amino acids, p-cyanophenylalanine, m-cyanophenylalanine, and S-cyanohomocysteine, have been introduced near the active site of the semisynthetic enzyme ribonuclease ...
The vibrational Stark effect (VSE) has proven to be an effective method for the study of electric fields in proteins via the use of infrared probes. To explore the use of VSE in nucleic acids, we inve...
Infrared spectroscopy is widely used to probe local environments and dynamics in proteins. The introduction of a unique vibration at a specific site of a protein or more complex assembly offers many a...
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a 5- or 6-coordinate Fe--NO heme complex. The H93G mutation replaces the proximal histidine of Mb with glycine, allowi...
Cholesterol is an essential component of mammalian cell membranes and it is important to regulate the structure and function of lipid bilayers. Changes in cholesterol levels are involved in many physi...
Polyketides are a broad class of natural products that have received attention from the scientific community because they are a rich mine of bioactive structures. The common thread that binds the clas...
The box corer is a relatively new tool used in the geotechnical community for collection of soft seabed sediments. Miniature full flow and model pipeline probes were developed as tools to characterize...
Galaxy clusters grow by mergers with other clusters and galaxy groups. These mergers create shocks within the intracluster medium (ICM). It is proposed that within the shocks particles can be accelera...
The discovery of many novel realizations of the inflationary universe paradigm has led to a degeneracy problem: many different inflationary Lagrangians generate the same perturbation spectra. Resolvi...
Measurements of the ground-state nuclear spins, magnetic and quadrupole moments of the copper isotopes from 61Cu up to 75Cu are reported. The experiments were performed at the ISOLDE facility, using t...
The discovery of many novel realizations of the in ationary universe paradigm has led to a degeneracy problem: many di erent in ationary Lagrangians generate the same perturbation spectra.Resolving th...
Static magnetic order of quasi two-dimensional FeAs compounds Sr4A2O6−xFe2As2, with A = Sc and V, has been detected by 57Fe M¨ossbauer and muon spin relaxation (μSR) spectroscopies. The non-sup...

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