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N-糖基化是蛋白质最普遍、复杂及重要的一种翻译后修饰之,位点特异的完整糖肽分析不仅能反映出特定糖型变化,并且可以指向特定的肽段及蛋白,近年来日益受到关注。然而,由于糖苷键和肽键碎裂能量不一致,各种质谱碎裂方式都只能获得部分定性信息,如高能碰撞裂解模式(Higher energy dissociation,HCD)下糖链产生糖和b/y型肽段片段,但可能导致在碎裂过程中失去全部或部分糖链修饰,而电子转...
National Science Review在线发表了中国科学院分子细胞科学卓越创新中心研究员季红斌研究组和中科院数学与系统科学研究院研究员王勇研究组合作的题为Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis的研究论文...
内质网自噬降解(ER-phagy)是近年来发现的一种选择性自噬途径,在细胞器更新和蛋白质降解中起着重要作用。其中,内质网到溶酶体的降解(ER-to-lysosome-associated degradation , ERLAD) 为蛋白质质量控制提供了一种不依赖蛋白酶体降解途径,对内质网更新和细胞内稳态至关重要,但它的作用过程和生物学功能尚未完全解明。目前用于研究这一过程的工具非常有限,其特异性的...
2019年12月24日,《国家科学评论》(National Science Review)杂志以“A Global-scale multidecadal variability driven by Atlantic Multidecadal oscillation”为题,刊登了我院韩籍校聘教授杨咏岷(Young-Min Yang)的最新科学研究。
中国科学院大连化学物理研究所黄延强研究员和张涛院士在肼分解制氢方面的工作受到了国际同行的广泛关注,近期受邀在《国家科学评论》(National Science Review)上发表题为“Design strategies of highly selective nickel catalysts for H2 production via hydrous hydrazine decompositio...
Stand back Wonder Woman, Doctor Who and Bruce Wayne. The National Science Foundation (NSF) is bringing some of its own superheroes to Awesome Con D.C. 2017. Hands-on demos of NSF-funded science and ta...
Today, the National Science Foundation (NSF) is usually associated with supporting scientists who go on to win Nobel Prizes, leading exploration of the planet's polar regions and enabling discoveries ...
To find new ways of halting the spread of Zika -- fast becoming a major public health threat -- the National Science Foundation (NSF) Division of Environmental Biology's Ecology and Evolutio...
The National Science Board (NSB) announced today that Robert J. Birgeneau is the recipient of the 2016 Vannevar Bush Award. Birgeneau is chancellor emeritus at the University of California, Berkeley a...
Dengue, yellow fever, Japanese encephalitis, West Nile virus -- and now Zika. Is our interaction with the environment somehow responsible for the increase in incidence of these diseases?Through a ...
Rapid changes are happening in the Arctic: ice cover is shrinking, permafrost is thawing. But what's happening to ground-dwelling species such as mosses? Mosses are critical parts of nutrient cycles ...
Rapid changes are happening in the Arctic: ice cover is shrinking, permafrost is thawing. But what's happening to ground-dwelling species such as mosses?Mosses are critical parts of nutrient cycles in...
The National Science Board (NSB) will meet Nov. 19-20, 2014, to address science and engineering policy of interest to the National Science Foundation (NSF). Members of the media and the public are inv...
Two scientists whose work was supported by the National Science Foundation (NSF) were among the 13 Nobel Prize winners announced earlier this month. During the last five years, 13 awardees have been ...
Today the White House announced its continued support for The BRAIN Initiative and revealed new commitments from non-federal agencies as part of the call to action to advance brain research. Governmen...

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