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The Effect of H1 Antagonists Carebastine and Olopatadine on Histamine Induced Expression of CC Chemokines in Cultured Human Nasal Epithelial Cells
allergic rhinitis carebastine CC chemokine histamine human nasal epithelial cells monocyte chemotactic protein-1 olopatadine RANTES
2010/11/18
The release of RANTES and MCP-1 was significantly upregulated by histamine compared with the control group. Both carebastine and olopatadine inhibited the release of CC chemokine production to the con...
Adrenomedullin stimulates cyclic AMP production in the airway epithelial cells of guinea-pigs and in the human epithelial cell line
adrenomedullin airway cAMP epithelial cell guinea-pig human
2010/11/26
This study was designed to examine the effects of adrenomedullin (AM) on airway epithelial cells. Primary cultures of guinea-pig tracheal epithelial cells and the human bronchiolar epithelial cell lin...
Differentiation of naive human CD4+ T cells into Th2 cells: The role of prostaglandin E2
interleukin naive CD4+ T cells prostaglandin E2 T-helper 2 cells
2010/11/26
T-helper (Th) 2 cells, which produce interleukin (IL)-4, IL-5, IL-10 and IL-13 upon stimulation of their T cell receptors, play an important role in the development of human allergic diseases. However...
Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils
basement membrane degradation eosinophil eotaxin matrix metalloproteinase-2 matrix metalloproteinase-9 membrane-type matrix metalloproteinase
2010/11/25
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily r...
Non-specific activation of human eosinophil functional responses by vasoactive intestinal peptide
allergic inflammation eosinophil functional response signal transduction vasoactive intestinal peptide
2010/11/25
Eosinophils and neuropeptides are thought to play effector roles in allergic diseases, such as rhinitis; however, little is known about the biological effects of neuromediators, especially vasoactive ...
Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts
fibronectin human lung fibroblast interleukin-4 interleukin-13 remodeling
2010/11/25
The results showed that IL-4 and IL-13 induced fibronectin production in a time- and a concentration-dependent manner. Anti-transforming growth factor (TGF)-β1 antibody (ab) inhibited TGF-β1-induced f...
Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
antiallergic drug human eosinophils leukotriene olopatadine
2010/11/25
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Effect of macrolides on the expression of human leukocyte antigen-DR and costimulatory molecules on cultured human mononuclear cells
CD54 CD80 CD86 costimulatory molecules human leukocyte antigen-DR macrolides monocytes
2010/11/25
Although the clinical effectiveness of long-term low-dose administration of macrolides for diffuse pan- bronchiolitis, sinobronchial syndrome, chronic sinusitis and otitis media with effusion has been...
Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
airway smooth muscle cell extracellular signal-regulated kinase mechanical strain
2010/11/25
An increased airway muscle content is one of the characteristic features of airway remodeling. Proinflammatory substances, growth factors and mechanical strain promote airway muscle cell proliferation...
Association of IgG Fc receptor II with tyrosine kinases in the human basophilic leukemia cell line KU812F
basophilic leukemia cell line IgG Fc receptor II intracellular calcium mobilization signal transduction tyrosine kinase
2010/11/24
The tyrosine kinase inhibitor genistein inhibited intracellular calcium mobilization caused by cross-linking of FcγRII in a dose-dependent manner. Rapid tyrosine phosphorylation after FcγRII cross-lin...
Human mast cell activation through Fc receptors and Toll-like receptors
adaptive immunity FcεRI FcγRI GeneChip innate immunity mast cell Toll-like receptor 4
2010/11/22
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...
Prostaglandin D2 and interleukin-5 reduce CRTH2 surface expression on human eosinophils
CRTH2 eosinophils interferon-γ interleukin-4 interleukin-5 prostaglandin D2
2010/11/22
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified. Because PGD2 was reported to have chemotac...
Suplatast Tosilate Inhibits Human Mast Cell Development from Cord Blood Progenitors
cord blood progenitors human mast cells stem cell factor suplatast tosilate
2010/11/19
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...
Platelet-activating Factor or Complement 5a Causes Distinct Activation Profiles in Human Eosinophil and Neutrophil Functions
adhesion complement 5a eosinophils neutrophils platelet-activating factor superoxide anion β2 integrin
2010/11/19
Eosinophils and neutrophils showed different activation profiles with stimulation of PAF or C5a on HSA-coated surfaces. In eosinophils the intensity of cellular adhesion and O2- release paralleled the...
Expression of Fas Antigen (CD95) on Human Leukemic Cells and Assessment of Apoptosis on Fas+ and Fas-Samples by Flowcytometry Method
Human Leukemic Cells Human Leukemic Cells
2010/4/26
Regulation of normal cell growth and turnover is balanced between cell pro¬liferation, cell differentiation and apoptosis.
A disruption of this balance is thought to be an important event leading...