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Hyalp1 in Murine Sperm Function:Evidence for Unique and Overlapping Functions With Other Reproductive Hyaluronidases
Sperm antigen, hyaluronidase activity Spam1 null sperm acrosome reaction cumulus penetration hyaluronic acid receptor
2008/12/24
While Sperm adhesion molecule 1 (SPAM1) is the highly conserved mammalian sperm hyaluronidase (hyase), multiple hyases are present in the mouse testis. In this study we show that one of the murine h...
Acute Effect of Vasectomy on the Function of the Rat Epididymal Epithelium and Vas Deferens
Crisp-1 clusterin osteopontin transferrin
2008/12/24
Persistent infertility after apparently successful vasectomy reversal is common. One possible etiology is epididymal epithelial dysfunction resulting in improper sperm maturation after vasectomy ...
Dose–Response Relationship Between Testosterone and Erectile Function: Evidence for the Existence of a Critical Threshold
Androgens erection neural NOS phosphodiesterase type 5 prostate
2008/12/24
Androgens play an important role in erectile function. However, the dose–response relationship between plasma testosterone levels and penile erection remains unclear. Intact (sham operated) or bi...
Sonic Hedgehog Pathway Inhibition Alters Epididymal Function as Assessed by the Development of Sperm Motility
Hedgehog genes epididymal regulation posttesticular sperm development
2008/12/23
The sonic hedgehog (Shh) signaling pathway plays a role in pattern orientation in the developing embryo and has been shown to be required for development of the prostate and external genitalia. Rece...
Supplementation of the Thawing Media With Reduced Glutathione Improves Function and the In Vitro Fertilizing Ability of Boar Spermatozoa After Cryopreservation
Pig spermatozoa oxidative stress IVF capacitation status
2008/12/23
In this study, we evaluated the effects of glutathione (L-g-glutamyl-L-cysteinylglycine; GSH) supplementation of the thawing extender on semen parameters to compensate for the decrease in GSH conten...
Tungstate Treatment Improves Leydig Cell Function in Streptozotocin-Diabetic Rats
Diabetes male reproductive performance
2008/12/23
Oral administration of sodium tungstate to adult male streptozotocin-diabetic rats for 3 months normalized serum levels of glucose, insulin, luteinizing hormone, and follicle-stimulating hormone. Th...
Impaired Sperm Function After Spinal Cord Injury in the Rat Is Associated With Altered Cyclic Adenosine Monophosphate Signaling
cAMP SYBR-14 JC-1
2008/12/23
Our previous observations of changes in the expression of cAMP-dependent genes and the cAMP-responsive element modulator (CREM) in rat testicular cells after spinal cord injury (SCI) implied abnor...
Cooling and Freezing of Boar Spermatozoa:Supplementation of the Freezing Media With Reduced Glutathione Preserves Sperm Function
Pig spermatozoa antioxidants cryopreservation in vitro fertilization capacitation status
2008/12/23
In this study, we evaluated the effects of glutathione (L--glutamyl-L-cysteinylglycine; GSH) supplementation of the freezing extender on semen parameters during the cooling (2 hours at 5°C) and free...
Tadalafil Improved Erectile Function at Twenty-Four and Thirty-Six Hours After Dosing in Men With Erectile Dysfunction:US Trial
Phosphodiesterase inhibitors efficacy successful sexual intercourse Sexual Encounter Profile (SEP) diary
2008/12/23
In a previous study assessing tadalafil for the treatment of erectile dysfunction (ED), tadalafil 20 mg was shown to improve erectile function for up to 36 hours vs placebo. This study sought to demon...
Rho-kinase Inhibition Improves Erectile Function in Aging Male Brown-Norway Rats
Muscle smooth drug effects penis physiology biological aging penile erection
2008/12/23
Physiological aging is a significant risk factor in the on-set of male erectile dysfunction (ED) and an imbalance in factors that modulate cavernosal smooth-muscle tone may play a role in these altere...
From the XXVII North American Testis Workshop:The Function of SMC and Other Cohesin Proteins in Meiosis
Function SMC Cohesin Proteins Meiosis
2008/12/22
To develop into haploid gametes, germ cells must undergo meiosis, a 2-step cell division process that is characterized by a sophisticated design in chromosome architecture and highly specific dynamic ...
Insulin-Dependent Diabetes Affects Testicular Function by FSH- and LH-Linked Mechanisms
Testes follicle-stimulating hormone luteinizing hormone
2008/12/22
A study was conducted to form a unified hypothesis regarding the gonadotropin-related mechanisms that underlie alterations in the male reproductive system in individuals with diabetes. Streptozotoci...
Testosterone,Sexuality,and Erectile Function in Aging Men
Testosterone Sexuality Erectile Function Aging Men
2008/12/19
Human aging is associated with many changes, which resemble those seen with deficiencies of sex steroids or growth hormone and with cortisol excess. Among these are decreases in lean body mass (LBM) a...
Neurophysiology of Erectile Function:Androgenic Effects
Neurophysiology Erectile Function Androgenic Effects
2008/12/19
Penile erection is a highly specialized vascular biologic process that requires regulatory control. Among the regulatory mechanisms contributing to this regulation, the nervous system is perceived to ...
Male Genital Tract Antioxidant Enzymes: Their Source, Function in the Female,and Ability to Preserve Sperm DNA Integrity in the Golden Hamster
Superoxide dismutase glutathione peroxidase catalase sperm DNA damage oxidative stress Syrian hamster
2008/12/19
Recently, we reported that male accessory sex gland (ASG) secretions protect sperm genomic integrity by demonstrating that DNA damage was more extensive in sperm not exposed to the secretions. The p...