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首都医科大学附属北京天坛医院江涛院士团队《Sig Transduct Target Ther》阐述CAR分子胞啃作用介导的CAR-T细胞失活与肿瘤抗原逃逸机制（图）
首都医科大学 北京天坛医院 肿瘤
2024/7/12
近日，首都医科大学附属北京天坛医院神经外科学中心江涛院士/张伟教授团队在《Sig Transduct Target Ther》在线发表题为“Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape”的封面研究论文。不同于以往研究报道的淋巴细胞作为“受者”获取肿瘤细胞抗原的经典胞啃现象...
A Revised Monte Carlo Method for Target Location with UAV
Monte Carlo Target location UAV Bias
2024/1/19
Target location using UAV equipped with vision system has played an important role in many applications but there remain challenges. One of the principal difficulties is to position a target with a hi...
pssRNAit-a web server for designing effective and specific plant siRNAs with genome-wide off-target assessment
Bioinformatics plant RNAi siRNA efficacy off-target gene silencing VIGS syntasiRNA
2024/1/12
We report an advanced web server named pssRNAit (plant specific small non-coding RNAi tool) that can be used to design a pool of small interfering RNAs (siRNAs) for highly effective, specific, and non...
Intelligent Sensing and Computing in Wireless Sensor Networks for Multiple Target Tracking
Intelligent Sensing Computing Wireless Sensor Networks Multiple Target Tracking
2023/11/20
With sixth generation (6G) communication technologies, target sensing can be finished in milliseconds. The mobile tracking-oriented Internet of Things (MTT-IoT) as a kind of emerging application netwo...
南京农业大学农学院《Plant Physiology》发表黄骥教授“RiceTFtarget: A Rice Transcription Factor-Target Prediction Server Based on Co-expression and Machine Learning”（图）
黄骥 基因 生物信息学 作物
2023/10/28
转录因子（TF）在基因表达调控中发挥了重要作用。鉴定转录因子的靶基因或与靶基因启动子结合的转录因子对于解析转录因子-靶基因模块的生物学功能和调控网络至关重要。2023年6月15日，作物生物信息学课题组在Plant Physiology发表了题为“RiceTFtarget: A Rice Transcription Factor-Target Prediction Server Based on C...
孔德新教授课题组Signal Transduct Target Ther报道：Stellettin B协同PARP抑制剂抗胶质母细胞瘤的作用及分子机制（图）
孔德新教授 天津医科大学 抑制剂
2023/7/8
天津医科大学药学院孔德新教授课题组近期在Signal Transduct Target Ther（IF=38.104）发表题为“Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair”的文章，报道了...
Researchers propose a list of Venus-like planets for James Webb Space Telescope to target（图）
金星 行星物理学 詹姆斯韦伯太空望远镜
2023/6/26
A team of researchers, including Brown planetary scientist Jim Head, propose using the James Webb Space Telescope to look at five planets in the Venus Zone, a search that could reveal valuable insight...
Cancer is characterized by a number of key biological processes known as the “hallmarks of cancer,” which remodel cells and their immediate environment so that tumors can form, grow, and thrive. Many ...
Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice
AM-relaxed Cas9 nucleases cytosine base editor adenine base editor off-target effect whole-genome sequencing genome editing rice
2023/7/20
PAM-relaxed Cas9 nucleases, cytosine base editors and adenine base editors are promising tools for precise genome editing in plants. However, their genome-wide off-target effects are largely unexplore...
于典司（2021）Genome-wide Comparative Analysis of Genetic Diversity of Regular and Specialty Maize Germplasms through Genotyping by Target Sequencing (GBTS) （图）
特用玉米 玉米种质 全基因组 GBTS
2023/2/27
上海市农业科学院作物育种栽培研究所玉米研究中心郑洪建团队在Plant Molecular Biology Reporter发表了题为“Genome-wide Comparative Analysis of Genetic Diversity of Regular and Specialty Maize Germplasms through Genotyping by Target Sequenci...
中南大学湘雅公共卫生学院黄瑞雪课题组在Signal Transduct Target Ther上发表论文（图）
中南大学湘雅公共卫生学院 黄瑞雪 Signal Transduct Target Ther 放射治疗 肿瘤治疗
2020/7/12
近日，中南大学湘雅公共卫生学院黄瑞雪课题组在Nature出版集团旗下期刊Signal Transduct Target Ther (IF:13.493)上在线发表了题为“DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer”的综述文章。
Astronomers find elusive target hiding behind dust（图）
Astronomers elusive target hiding behind dust
2020/6/19
Astronomers acting on a hunch have likely resolved a mystery about young, still-forming stars and the regions rich in organic molecules closely surrounding some of them. The scientists used the N...
New probe developed to detect a common target for anti-inflammatory drugs（图）
New probe developed detect common target anti-inflammatory drugs
2020/3/6
Scientists have developed a probe named CoxFluor that can distinguish between Cyclooxygenase-2, an enzyme that plays a major role in driving the progression of cancer, and the enzyme Cyclooxygenase-1,...
Hong Kong government awards largest target-cost NEC contract
Hong Kong government largest target-cost NEC contract
2019/10/9
The Hong Kong Highways Department (HyD) has marked 10 years of growing NEC use in the territory by letting the government’s largest NEC target contract to date.
Everybody's a Target: Scalability in Public-Key Encryption
public-key cryptography key encapsulation, mass surveillance elliptic-curve cryptography (ECC)
2019/4/10
For 1≤m≤n1≤m≤n, we consider a natural mm-out-of-nn multi-instance scenario for a public-key encryption (PKE) scheme. An adversary, given nn independent instances of PKE, wins if he breaks at least mm ...