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2022年3月29日下午15:00，细胞生物学与遗传学教研室王亮博士应邀在基础医学与法医学院学术厅开展了题为“SIRT1-Snail介导的细胞连接在炎症性肠病中的作用机制及干预研究”的学术讲座。师生共三十余人参加了本次讲座，讲座由基法学院副院长汤建才主持。
New native Hawaiian land snail species discovered（图）
New native Hawaiian land snail species discovered
2020/7/31
Scientists at the Florida Museum of Natural History and other institutions have discovered a new native Hawaiian land snail species, sounding a rare, hopeful note in a story rife with extinc...
转录因子Snail介导E-cadherin表达在食管鳞癌迁移和侵袭中的作用
食管鳞癌 Snail E-cadherin 迁移 侵袭
2020/3/19
探索转录因子Snail、Ecadherin基因在食管鳞癌中的表达及临床病理意义，明确其对食管鳞癌迁移和侵袭的影响。方法：食管鳞癌组织及对应癌旁组织标本30例，PCR检测Snail、Ecadherin表达；以癌/癌旁组织相对表达量表示Snail及Ecadherin在mRNA水平表达的差异，分析其与临床病理特征间关系；随机抽取其中4例，Western blot检测Snail、Ecadherin...
3D characteristics of ADCP echo intensity anomaly observed over the Snail, Archean, and Pika hydrothermal vent fields in the South Mariana Trough
South Mariana Trough hydrothermal plume AUV 3D mapping ADCP echo intensity
2017/4/10
We conducted four dives using the Urashima autonomous underwater vehicle (AUV) over three hydrothermal vent
fields (Snail, Archean, and Pika) within the South Mariana Trough in July 2009, and measure...
The Phylogeography of Marstonia Lustrica: Understanding the Relationship Between Glaciation and the Evolution and Distribution of a Rare Snail
gastropod glacier Marstonia phylogenetics phylogeography snail
2014/12/9
Marstonia lustrica is a poorly understood aquatic snail, relatively rare throughout its range and listed in the State of Massachusetts as Endangered (MNHESP 2010, Hershler et. al 1987). It is the nort...
Snail shells show high-rise plateau is much lower than it used to be
Snail's shell high-rise climate
2014/10/9
The Tibetan Plateau in south-central Asia, because of its size, elevation and impact on climate, is one of the world’s greatest geological oddities.
The Zhada Basin on the southwest Tibetan Plateau, ...
Dispersal at a Snail’s Pace: Historical Processes Affect Contemporary Genetic Structure in the Exploited Wavy Top Snail (Megastraea undosa)
fisheries larval dispersal management
2015/12/11
We used population genetics to assess historical and modern demography of the exploited wavy top snail, Megastraea undosa,
which has a 5–10 day pelagic larval duration. Foot tissue was sampled from ...
观察锌指转录因子snail在耐顺铂（cisplatin,CDDP）的人小细胞肺癌(small cell lung cancer, SCLC)H446/CDDP细胞中的表达情况，探讨snail表达在人SCLC顺铂耐药中的作用。 方法 培养H446细胞系和H446/CDDP细胞系，采用MTT法检测H446/CDDP的耐药指数；分别提取人SCLC顺铂耐药细胞H446/CDDP及其亲代...
上皮-间质转化（epithelial mesenchymal transition, EMT）是肿瘤浸润和转移的关键步骤，上皮细胞极性丧失是其主要标志，表现为Claudin等上皮标记丢失。锌指转录因子Snail是调控EMT的重要转录因子，近年来对肿瘤侵袭转移机制研究发现Snail能提高多种肿瘤的侵袭能力。本研究旨在利用组织芯片技术探讨转录因子Snail和紧密连接蛋白（Claudin-3）在非小细胞...
研究信号转导与转录激活因子3（STAT3）基因转染人胃癌细胞株SGC7901后，对锌指转录因子Snail1（Snail）及切除修复交叉互补基因1（excision repair cross complementation group 1，ERCC1）表达的影响。
三氧化二砷联合非诺贝特对人肺癌A549细胞上皮间质转化及E-cadherin/Snail转化因子的影响
三氧化二砷 非诺贝特 肺肿瘤 上皮-间质转化 E-cadherin Snail
2012/10/23
观察三氧化二砷和非诺贝特单独及联合运用对人肺癌A549细胞上皮间质转化及相关因子E-cadherin、Snail的影响。 方法 体外培养人肺癌A549细胞，根据处理因素不同分为4组，A组：阴性对照组（只含有DMEM培养液）；B组：1 μmol/L三氧化二砷单药处理组；C组：100 μmol/L非诺贝特单药处理组；D组:1 μmol/L三氧化二砷+100 μmol/L非诺贝特联合...
探讨上皮间质转化（EMT）与转录因子Twist及Snail在宫颈鳞状上皮病变发生发展过程中的作用及意义。 方法 选择荆州市妇幼保健院2005年1月至2009年12月宫颈组织活检及手术切除中，确诊为宫颈鳞状上皮病变的170例存档石蜡块标本为研究对象。其中，慢性宫颈炎标本为20例，纳入慢性宫颈炎标本组；CINⅠ，CINⅡ，CINⅢ及宫颈鳞癌标本各为32例，27例，35例及56例，分别纳入CINⅠ组，C...
观察宫颈上皮内瘤变及宫颈鳞状细胞癌中Twist和Snail的表达情况以及探讨两者在宫颈癌变过程中的作用和意义。方法 研究原位杂交检测宫颈上皮内瘤变(CINⅠ、Ⅱ、Ⅲ)及宫颈鳞癌组织标本中Twist、Snail的表达情况，另设20例慢性宫颈炎组织标本作为对照。结果 慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ、宫颈癌组中：Twist、Snail的阳性率分别是10%、28.1%、29.6%、42.9%、6...
Snail及N-cadherin蛋白在骨肉瘤中的表达及其与预后的关系
N-cadherin 骨肉瘤 免疫组织化学 预后分析
2013/12/25
观察Snail及N-cadherin蛋白在骨肉瘤中的表达，探讨其在骨肉瘤发生发展、浸润转移的作用及其与预后的关系。方法采用免疫组织化学SP法检测38例骨肉瘤组织、20例骨软骨瘤组织中Snail及N-cadherin蛋白的表达。结果(1)Snail、N-cadherin蛋白在骨肉瘤中表达均高于它们在骨软骨瘤组织中的表达，其差异有统计学意义(χ2=27.375，P<0.01；χ2=21.849P<0....