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南京农业大学农学院《Nucleic Acids Research》发表张文利教授团队“The roles of DNA methylation on pH dependent i-motifs (iMs) formation in rice”（图）
张文利 基因 解析
2024/6/11
2024年1月8日，农学院张文利课题组在 “Nucleic Acids Research”上发表了题为“The roles of DNA methylation on pH dependent i-motifs (iMs) formation in rice”的研究论文。该研究是在前期的研究基础之上（Nucleic Acids Res 2022, 50:3226-3238），再次利用iM-IP-s...
UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis
DNA methylation Light responses Plant signalling
2023/12/11
DNA methylation is an important epigenetic gene regulatory mechanism conserved in eukaryotes. Emerging evidence shows DNA methylation alterations in response to environmental cues. However, the mechan...
南京农业大学农学院《Plant Cell》发表宋庆鑫教授团队“Asymmetric variation of DNA methylation during domestication and de-domestication of rice”（图）
宋庆鑫 水稻栽培 基因
2023/10/28
水稻是全球最为重要的粮食作物之一，在其漫长的驯化过程中形成了形态各异的水稻栽培亚型，包括粳稻、籼稻、Aro和Aus等。在水稻栽培种植历史过程中，有些水稻逐渐恢复部分野生稻表型特征，最终演化成严重威胁全球水稻产量的杂草稻，这种现象称之为“去驯化”。通过基因组进化研究发现，大量驯化位点的变异在去驯化过程中并不能得到恢复，这就暗示着可能存在别的遗传机制来调控杂草稻在去驯化过程中恢复野生稻表型。DNA甲基...
南京农业大学农学院《PNAS》发表水稻抗病遗传育种课题组“The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice”（图）
水稻抗病 遗传育种 转基因育种
2022/3/23
2021年7月22日，“作物遗传与种质创新国家重点实验室”的水稻抗病遗传育种课题组在《PNAS》在线发表了题为“The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice”的研究论文（Article）。...
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial
DNA methylation epigenetics EWAS Illumina 450k methylation array LIPOGAIN cohort obesity overfeeding polyunsaturated fat prediction saturated fat
2018/11/13
Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) h...
Repeats as global DNA methylation marker in bovine preimplantation embryos
epigenetics retrotransposon bisulfite sequencing
2017/2/21
DNA methylation undergoes dynamic changes and is a crucial part of the epigenetic regulation during mammalian early development. To determine the DNA methylation levels in bovine embryos, we applied a...
Characterization of the Methylation Status of Pax7 and Myogenic Regulator Factors in Cell Myogenic Differentiation
Pax7 Myogenic Regulatory Factors C2C12 DNA Methylation CpG Islands
2016/7/27
Epigenetic processes in the development of skeletal muscle have been appreciated for over a decade. DNA methylation is a major epigenetic modification important for regulating gene expression and supp...
Postprandial alterations in whole-blood DNA methylation are mediated by changes in white blood cell composition
DNA methylation food intake ghrelin HumanMethylation450k EWAS
2018/12/13
Background: DNA methylation is an essential nuclear process associated with genomic functions such as transcription factor binding and the regulation of gene expression. DNA methylation patterns can a...
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium
DNA methylation epidemiology fatty acids genetic variants plasma lipids
2018/11/28
Background: DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression.
Analysis of Histone Lysine Methylation Using Mass Spectrometry
MudPIT histones transcription
2015/5/25
Histones are highly basic proteins which when digested by trypsin are hard to analyze using mass spectrometry. Because histones are basic nuclear proteins, a nuclei prep followed by acid extraction is...
LIM homeodomain 3 (LHX3) is an important regulator of pituitary and nervous system development. To date, twelve LHX3 gene mutations have been identified in patients with combined pituitary hormone def...
A new strategy for RNA structure probing in vivo: Targeting methylation small nucleolar RNPs to new sites in ribosomal RNA
Eukaryotic ribosomal RNA nucleotide RNA proteins DNA methylation
2014/12/11
Eukaryotic ribosomal RNAs (rRNAs) contain scores of 2′-O-methylated nucleotides that are formed by a large family of small RNA:protein machines called snoRNPs. The snoRNPs contain a small nucleolar RN...
Innate immune responses to B. burgdorferi mediated by JNK1 and the cochaperone, methylation controlled DNAJ (MCJ)
Innate immune responses B. burgdorferi mediated JNK1 the cochaperone methylation controlled DNAJ
2014/10/23
The infections agent of Lyme disease, Borrelia Burgdorferi is a complex microorganism with a highly diverse genome. One of the most remarkable aspects of the B. burgdorferi genome is the large number ...
Association of DNA Methylation Levels with Tissue-specific Expression of Adipogenic and Lipogenic Genes in Longissimus dorsi Muscle of Korean Cattle
Adipogenesis DNA Methylation Intramuscular Fat Korean Cattle
2016/5/17
Epigenetic factors, such as DNA methylation status, may regulate adipogenesis and lipogenesis, thus affecting intramuscular fat (IMF) deposition in longissimus dorsi muscle (LM) of beef cattle. In Kor...