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造血干细胞（Hematopoietic Stem Cell，HSCs）的损伤耗竭与白血病干细胞（Leukemia Stem Cells，LSCs）的治疗耐药性是重大血液系统疾病治疗困难的主要原因。因此，解析HSC和LSC稳态维持的异同，开发靶向LSCs的清除策略具有重要的研究意义。近日，血液领域国际著名期刊Leukemia在线发表了暨南大学衰老与再生医学研究院鞠振宇研究员，陈陟阳研究员，暨南大学附...
浙江大学生命科学研究院2022年1月17日沈立实验室在Leukemia合作发文解析HMCES对长期造血干细胞的保护作用并提出白血病治疗的新靶点（图）
沈立 造血干细胞 白血病治疗 新靶点
2022/10/25
长期造血干细胞（long-term hematopoietic stem cell, LT-HSC）通过自我更新和多向分化维持机体的终身造血。在稳态下，这群稀有的成体干细胞通过保持静息状态以减少活性氧（ROS）的产生从而保证其基因组的稳定性。然而，当遭受造血压力刺激时，LT-HSC会退出静息状态并快速活化和增殖，从而导致细胞内的ROS水平迅速升高，进而产生无碱基位点（AP位点）等DNA氧化损伤。当...
华南理工大学医学院张文清课题组在Leukemia发文，发现斑马鱼Asxl1基因突变影响中性粒细胞发育（图）
华南理工大学医学院 张文清 Leukemia 斑马鱼 Asxl1基因突变影响 中性粒 细胞发育
2021/2/23
髓系恶性肿瘤（myeloid malignancies）是一类严重影响人类生命健康的血液疾病，它主要包括慢性阶段的骨髓增生异常综合征（myelodysplastic syndromes，MDS）、骨髓增生性肿瘤（myeloproliferative neoplasms，MPN）、慢性粒单核细胞白血病（chronic myelomonocytic leukemia，CMML）和急性阶段的急性髓系白血...
近日，我校在读博士王莹、李护君，及朱峰副教授在CAR-T疗法的临床研究方面取得了新的进展，相关结果分别发表在血液学领域权威期刊《Leukemia》（JCR 1区 TOP期刊 IF：9.9）和《Bone Marrow Transplantation》（JCR 1区）。论文题目：Safety and efficacy of chimeric antigen receptor (CAR)-T-cell ...
近日，宁波大学医学院金晓锋博士在肿瘤领域取得重大科研成果。金晓锋以第一作者在肿瘤领域国际顶级期刊《Leukemia》上发表题为《CRL3-SPOP Ubiquitin Ligase Complex Suppresses the Growth of Diffuse Large B-cell Lymphoma by Negatively Regulating the MyD88/NF-κB Signa...
由上海交通大学基础医学院细胞凋亡与分化教育部重点实验室洪登礼和陈国强课题组、上海交通大学医学院附属上海儿童医学中心汤燕静教授和中国科学院动物研究所刘峰研究员共同合作完成的一项成果揭示了胚胎造血调控因子FEV的表达可以指示出生前起源的白血病，该成果于2016年12月9日以“Expression of the fetal hematopoiesis regulator FEV indicates le...
Association of body mass index and survival in pediatric leukemia: a meta-analysis
obesity pediatric leukemia relapse survival nutritional status
2018/11/28
Background: Obesity is a worldwide epidemic in children and adolescents. Adult cohort studies have reported an association between higher body mass index (BMI) and increased leukemia-related mortality...
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer
Xenotropic Murine Leukemia Virus-Related Virus Polymorphism RNase L Prostate Cancer
2015/12/29
Background: Although several studies have confirmed the association of xenotropic murine leukemia virus-related virus (XMRV) and prostate cancer, this association is still controversial, as most studi...
Researchers find new clue to halting leukemia relapse
Researchers halting leukemia relapse
2015/9/18
A protein domain once considered of little importance may be key to helping patients who are fighting acute myeloid leukemia (AML) avoid a relapse.Researchers at Rice University, working wit...
肿瘤医院放射治疗科李晔雄教授领导的NK/T细胞淋巴瘤全国多中心协作组开展的结外鼻型NK/T细胞淋巴瘤列线图（Nomogram）研究日前在世界顶尖级肿瘤杂志《Leukemia》发表（2014年IF 10.43）。这一研究在国际上首次提出了结外鼻型NK/T细胞淋巴瘤的列线图模型，该模型可对治疗前患者进行疾病风险评分，并预估患者5年总生存率。该模型的建立可为后续基于风险分层的治疗决策提供依据。
Chronic Myeloid Leukemia with Variant Chromosomal Translocations:Results of Treatment with Imatinib Mesylate
Chronic myeloid leukemia Imatinib Variant translocation
2015/7/10
Objective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
Influence of Endurance Exercise on the Risk of Pneumonia and Fever in Leukemia and Lymphoma Patients Undergoing High Dose Chemotherapy. A Pilot Study
Exercise chemotherapy cancer pneumonia fever activity
2015/5/13
Pneumonia and fever are common side effects of high dose chemotherapy (HDC). The positive influence of physical activity on physiological and psychological parameters in cancer patients has been demon...
An 8-year-old Friesen mare was admitted to the Equine Clinic, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic with ventral edema and weight loss which had proceeded over the...