搜索结果: 1-15 共查到“de novo”相关记录30条 . 查询时间(0.046 秒)
UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis
DNA methylation Light responses Plant signalling
2023/12/11
DNA methylation is an important epigenetic gene regulatory mechanism conserved in eukaryotes. Emerging evidence shows DNA methylation alterations in response to environmental cues. However, the mechan...
De novo phasing resolves haplotype sequences in complex plant genomes
de novo phasing haplotype-resolved assembly autopolyploid chromosomal rearrangement
2023/11/28
Genome phasing is a recently developed assembly method that separates heterozygous eukaryotic genomic regions and builds haplotype-resolved assemblies. Because differences between haplotypes are ignor...
南京农业大学农学院《Nature Communications》上发表甘祥超教授团队“GALA: a computational framework for de novo chromosome-by-chromosomeassembly with long reads”（图）
甘祥超 植物育种 动物基因
2023/10/28
2023年2月22日，南京农业大学农学院甘祥超教授与其原德国马克斯·普朗克植物育种研究所团队在《Nature Communications》上发表题为“GALA: a computational framework for de novo chromosome-by-chromosomeassembly with long reads”的研究论文，并发布了相应的开源软件GALA (http://g...
中国科学院南海海洋研究所科研人员建立原噬菌体de novo预测新算法（图）
原噬菌体 de novo预测
2022/10/20
中国科学院南海海洋研究所研究员王晓雪团队建立了一种不依赖于噬菌体基因序列相似性的原噬菌体de novo预测新算法，集成分析流程的工具名为Prophage Tracer。相关研究2021年9月22日在线发表于《核酸研究》。汤开浩博士为论文第一作者，王晓雪为通讯作者。来自天津生物芯片技术有限责任公司的孙亚民博士也参与基因组分析工作。
中国科学院上海药物研究所徐华强课题组与合作团队首次解析de novo DNA甲基转移酶和天然底物核小体的高分辨率结构（图）
中国科学院上海药物研究所 徐华强 de novo DNA甲基转移酶 天然底物 核小体 高分辨率
2020/10/19
中科院上海药物研究所徐华强课题组与美国温安洛研究所Peter Jones课题组、Karsten Melcher课题组于北京时间2020年9月23日在国际顶级期刊《NATURE》在线发表了题为“Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B”的重要研究成果。研究团队利用Cryo-EM技术首次解析了de no...
人心果转录组De novo组装及奇可胶途径相关基因的分析
人心果 转录组 奇可胶
2018/8/1
为了探索人心果（Manilkara zapota L.）的转录组及奇可胶合成相关的基因，使用Illumina测序平台，对人心果果实、树皮和叶片分别进行转录组测序，使用Trinity等软件进行De novo组装和注释以及计算表达量，采用实时荧光定量PCR对转录组数据进行验证。经过组装得到162 455条unigene，总长度达139 792 553 nt，平均长度达861 nt，N50达1 544 ...
利用RNA seq技术对中华蜜蜂（Apis cerana cerana，简称中蜂）幼虫肠道参考转录组进行de novo组装，并进行功能及代谢通路注释，进而利用该转录组数据进行中蜂幼虫的SSR分子标记鉴定。【方法】实验室条件下饲养中蜂幼虫，将纯化的蜜蜂球囊菌（Ascosphaera apis，简称球囊菌）孢子饲喂3日龄幼虫，剖取4、5和6日龄幼虫肠道，液氮速冻。将健康幼虫肠道与感染球囊菌的幼虫肠道同...
【目的】通过RNA seq技术对纯培养的蜜蜂球囊菌Ascosphaera apis孢子和球囊菌侵染的蜜蜂幼虫肠道组织进行测序，de novo组装球囊菌的参考转录组，并对其进行功能与代谢通路注释，进而基于该转录组数据开发球囊菌的SSR分子标记。【方法】首先通过差速离心获得活化的球囊菌孢子，配制含1×107孢子/mL的饲料饲喂4，5和6日龄的意大利蜜蜂Apis mellifera ligustica幼...
De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women
De novo lipogenesis deuterium overfeeding
2016/6/14
The results of previous studies suggest that de novo
lipogenesis may play an important role in the etiology of obesity,
particularly during overconsumption of different carbohydrates.
No common energy currency: de novo lipogenesis as the road less traveled
lipogenesis energy currency
2016/6/14
Bees make wax (lipid) from honey (carbohydrate). Pigs fatten
on a grain diet. Indeed, all organisms, from bacteria to mammals,
have the enzymes of de novo lipogenesis. The physiologic
function of d...
Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men
Obesity hyperinsulinemia carbohydrates
2016/6/12
Adjustments of carbohydrate intake and oxidation
occur in both normal-weight and overweight individuals. Nevertheless,
the contribution of carbohydrates to the accumulation of
fat through either re...
De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption
lipolysis hypertriglyceridemia acetate
2016/6/2
Acute alcohol intake is associated with changes in
plasma lipid concentrations and whole-body lipid balances in
humans. The quantitative roles of hepatic de novo lipogenesis
(DNL) and plasma acetat...
Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis–derived endogenous glutamine production
Glutamine glutamic acid muscles
2016/6/1
Results of tracer studies indicate that skeletal muscle
contributes to <70% of overall glutamine production in
healthy adults; the contribution of de novo synthesis being estimated
at <60%. However...
Fictional Models de Novo and de Re
Modeling Fiction Kendal Walton Amie Thomasson Roman Frigg
2016/5/30
Fictional Models de Novo and de Re.
Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder
Identification functional characterization novo FOXP1 variants neurodevelopmental disorder
2016/5/3
De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related disorder identif...