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鸡Visfatin蛋白的原核表达、纯化及其活性研究
鸡重组Visfatin 克隆 原核表达 条件优化 3T3-L1
2016/10/31
本试验旨在通过克隆Visfatin基因，将其在原核表达系统中表达并纯化，通过3T3-L1细胞的分化验证其活性，成功获得鸡重组Visfatin蛋白。以AA肉仔鸡肝组织总RNA为模板，qRT-PCR扩增Visfatin基因，转化进入pGEM-T载体，再与原核表达载体pET-30a连接转化，获取含pET-30a-Visfatin重组质粒的E.coli BL21(DE3)表达菌株。以IPTG诱导重组菌株...
The visfatin (NAMPT; PBEF1) gene polymorphisms and associations with meat performance traits in three pig breeds kept in the Czech Republic
visfatin NAMPT PBEF
2015/6/8
Visfatin encoded by the NAMPT gene (nicotinamide phosphoribosyltransferase, formerly also known as PBEF ?pre-B cell colony-enhancing factor) is suggested to play a role in lipid metabolism and pathoph...
Effects of 12 Weeks of Combined Exercise Training on Visfatin and Metabolic Syndrome Factors in Obese Middle-Aged Women
Metabolic syndrome combined resistance aerobic exercise visfatin
2015/5/6
Visfatin is a highly expressed protein with insulin-like functions located predominantly in visceral adipose tissue and has been linked to obesity and increased health risks. The purpose of this study...
Effect of Biochanin A on Serum Visfatin Level of Streptozocin-Induced Diabetic Rats
Visfatin Biochanin A Diabetic Rats
2015/10/14
Background: Bioflavonoids are well known for their multi directional biologic activity including antidiabetic effect. It has been demonstrated that flavonoids can act as insulin secretagogue or insuli...
检测2型糖尿病肾病患者血清visfatin、Apelin水平，探讨其在2型糖尿病肾病发生发展中的作用及临床意义。方法 根据24 h尿微量白蛋白排泄率(UAER)将105例2型糖尿病患者分为正常白蛋白尿组(NA组，39例)、微量白蛋白尿组(MA组，36例)、临床白蛋白尿组(CP组，30例)，选取健康者作为对照组(NC组，35例)。采用酶联免疫吸附法(ELISA)测定血清visfatin、Apelin...
Limiting Concentrate during Growing Period Affect Performance and Gene Expression of Hepatic Gluconeogenic Enzymes and Visfatin in Korean Native Beef Calves
Calf, Concentrate, Growth, Gluconeogenic Enzymes, Plasma
2016/5/11
This study elucidated the effects of limited concentrate feeding on growth, plasma profile, and gene expression of gluconeogenic enzymes and visfatin in the liver of Hanwoo beef calves. The purpose of...
Visfatin levels are low in subjects with type 2 diabetes compared to age-matched controls
Visfatin Adiponectin Resistin Diabetes Insulin Resistance
2013/1/30
Background: Visceral adiposity correlates strongly with insulin resistance and components of metabolic syndrome. Visfatin is preferentially produced by human visceral adipose tissue. Objective: The ob...
脂肪因子是由脂肪组织分泌的肽类物质， 影响着整个机体的能量代谢， 在多种病理过程中起着关键性调节作用。PBEF/Nampt/Visfatin是2005 日本学者新发现的一种脂肪因子， 由于其具有类胰岛素作用而成为研究热点。目前对该因子属性、作用及作用机制的探讨十分激烈。尽管对PBEF/Nampt/Visfatin的认识尚未明了， 但其在代谢性疾病中的作用为该类疾病的病理机制做了重要补充， 并且为攻...
Variation in the visfatin gene may alter the required dosage of oral antidiabetic agents in type 2 diabetic patients
Visfatin Genotype Antidiabetic agents HOMA QUICKI Type 2 diabetes
2009/11/24
Background: Treatment of diabetes with oral antidiabetic agents is accompanied by considerable variability in pharmacokinetics and clinical efficacy. Genetic factors may contribute to individual diffe...
Cord Plasma Concentrations of Visfatin, Adiponectin and Insulin in Healthy Term Neonates: Positive Correlation with Birthweight
adiponectin visfatin insulin birthweight
2009/10/26
Objective: The aims of this study were to examine the relationships between adiponectin, insulin, visfatin and weight at birth in healthy term infants. Design and methods: Anthropometric parameters in...
Visfatin是新发现的由内脏脂肪细胞分泌的一种脂肪细胞因子，可结合并激活胰岛素受体的非胰岛素结合部位，激活胰岛素受体信号通路，从而模拟胰岛素作用，降低机体血糖。这一因子还能够促进脂肪组织的分化、合成及积累。Visfatin cDNA序列与前B细胞克隆增强因子（PBEF）相同，Visfatin在细胞内尚发挥尼克酰胺磷酸核糖转移酶(Nampt)的作用，通过调节氧化型辅酶I（NAD）的生成从而调控S...
Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men1,2,3
Visfatin insulin resistance lipids body composition nutritional regulation
2008/12/10
Background:Visfatin is an insulin-mimicking adipokine. Visfatin is elevated in obesity and type 2 diabetes. However, its role in glucose and lipid metabolism in healthy humans is unclear.Objective:The...