搜索结果: 1-15 共查到“Phenotype”相关记录32条 . 查询时间(0.091 秒)
'Rules of Life' outlines path to predicting phenotype（图）
Rules of Life outlines path predicting phenotype
2017/9/4
Imagine a world where scientists can predict with confidence whether crops will grow in extreme temperatures, just by understanding their genetic makeup. Consider a future where doctors can know what ...
Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype
cholecystokinin obesity drug development hormonal responsiveness population study cholesterol epidemiology
2018/11/15
Background: Cholecystokinin (CCK) is an important satiety factor, acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clinical trials for obesity. We postu...
Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype
malnutrition metabolome metabolic phenotype metabolome metabonomics microbiome microbiota, protein deficiency undernutrition
2018/12/18
Background: Environmental enteropathy, which is linked to undernutrition and chronic infections, affects the physical and mental growth of children in developing areas worldwide. Key to understanding ...
Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
apolipoproteins atherosclerosis cholesterol coronary heart disease diet
2018/11/28
Background: In general populations, the effects of dietary cholesterol on blood cholesterol concentrations are modest. However, the relation is stronger in those with an ɛ4 allele in the apolipop...
Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
CVD risk isoflavone flavonoids vascular function equol producer phenotype arterial stiffness
2018/11/28
Background: There is much speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived metabolite of the isoflavone daidzein, which is produced in the large intesti...
Punctuated equilibrium in statistical models of generalized coevolutionary resilience: How sudden ecosystem transitions can entrain both phenotype expression and Darwinian selection
coevolution cognitive paradigm gene expression information theory
2015/7/29
We argue, using a mathematical model based on asymptotic limit theorems of probability theory, that mesoscale ecosystem resilience shifts can entrain punctuated events of gene expression and other cog...
EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
hypoxia cancer HIF
2015/5/25
High choline uptake and increased choline kinase activity have been reported in many cancers. This has motivated the use of choline as a biomarker for tumor imaging. Tumors in general are heterogeneou...
Lymph node and peri-lymph node stroma : phenotype and interaction with T-cells
Ly51 iNOS IDO1
2015/5/21
The non-hematopoietic, stationary stromal cells located inside and surrounding skin-draining lymph nodes play a key role in regulating immune responses. We studied distinct populations of lymph node s...
Phenotype features in juvenile populations of Picea abies and their growth
anatomy height growth needle types
2015/5/5
The young populations of Norway spruce (Picea abies) can be evaluated in terms of both variability in
the quantitative characteristics and share of different phenotypes according to the needle types...
Patterns and Severity of Crown Dieback in Young Even-Aged Stands of European Ash (Fraxinus excelsior L.) in Relation to Stand Density, Bud Flushing Phenotype, and Season
Hymenoscyphus pseudoalbidus crown damage
2015/3/10
The extent and temporal pattern of crown damage (attributed to Hymenoscyphus pseudoalbidus) in even-aged stands of
Fraxinus excelsior in relation to bud flushing phenotype, stand density, and season...
Prevalence of Listeria monocytogenes in milk, meat and foodstuff of animal origin and the phenotype of antibiotic resistance of isolated strains
pathogenic bacteria acquired resistance food safety
2015/2/5
In 2000–2002 samples of raw materials (milk and beef, 518 samples), ready-to-cook foods and final products from milk (30 and 200 samples) and from meat (105 and 110 samples) and swabs from surfaces in...
Evidence of an Infectious Asthma Phenotype: Chlamydia Driven Allergy and Airway Hyperresponsiveness in Pediatric Asthma
allergy asthma atopy chlamydia hyperresponsivness
2015/1/28
Asthma is the most common chronic respiratory disease affecting young children and adults all over the world. An estimated 34.1 million Americans have reported asthma in their lifetime and the disease...
TRAF-interacting protein, an inhibitor of the canonical nuclear factor-kappaB pathway, plays a key role in the estradiol -dependent apoptosis of the dual-phenotype gamma amino butyric acid/glutamate neurons in the anteroventral periventricular nucleus of the male rat
Mediated estradiol LH surge neurons male AVPV E2 - mediated cell death neurons
2014/12/11
The anteroventral periventricular nucleus (AVPV) of the preoptic area mediates the positive feedback effects of estradiol (E2) on LH surge in rats. Consistent with their role in female reproduction, t...
Regulation and Action of Skp2 and Rhoa in Cell and Tumor Models: Investigation into the Molecular Mechanisms Responsible for the Aggressive Phenotype of Triplenegative Breast Cancer
Basal-Like Breast Cancer Cell Cycle p27 proliferation SKP2 Triple-Negative Breast Cancer
2014/12/10
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights in...
Inflammatory Genes and Psychological Factors Predict Induced Shoulder Pain Phenotype
CHRONIC,PAIN MUSCLE,PAIN INFLAMMATION,SNP IL1B TNF/LTA,REGION IL6
2017/5/24
The pain experience has multiple influences, but little is known about how specific biological and psychological factors interact to influence pain responses. The current study investigated the combin...