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2017 I型干扰素 Keystone Symposia（2017 Keystone Symposia on Type I Interferon: Friend and Foe Alike）
Immune Signal Nucleic Acids
2017/1/13
The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary sessio...
The role of STAT1 in Chlamydia-induced type I interferon responses in oviduct epithelium
type I interferon TLR oviduct epithelium
2015/5/21
Progression of Chlamydia into upper reproductive tract epithelium and the induction of subsequent immune responses to infection are major contributors to Chlamydia-induced pathogenesis of the genital ...
DISTINCT LOCALIZATION OF NADPH OXIDASE FLAVOCYTOCHROME B IN RESTING AND INTERFERON GAMMA ACTIVATED MACROPHAGES
Host defense superoxide
2015/5/21
Flavocytochrome b558, the catalytic core of the phagocytic NADPH oxidase, mediates the transfer of electrons from NADPH to molecular oxygen to generate superoxide for host defense. Flavocytochrome b i...
Regulation of Interferon-stimulated Gene (ISG)12, ISG15, and MX1 and MX2 by Conceptus Interferons (IFNTs) in Bovine Uterine Epithelial Cells
IFNT Isoforms ISG MX Uterus
2016/5/11
Various endometrial genes in ruminant ungulates are regulated by conceptus interferon tau (IFNT). However, the effect of each IFNT isoform has not been carefully evaluated. In this study, the effects ...
Presence of Transcription Factor OCT4 Limits Interferon-tau Expression during the Pre-attachment Period in Sheep
Interferon-tau Transcription Gene regulation Implantation Sheep
2016/5/11
Interferon-tau (IFNT) is thought to be the conceptus protein that signals maternal recognition of pregnancy in ruminants. We and others have observed that OCT4 expression persists in the trophectoderm...
Interferon-Beta-1b Induced Autoimmune Hemolytic Anemia in a Patient with MS: A Case Report
Multiple sclerosis Interferon beta Haemolytic anemia
2015/9/22
A 26-year old lady with the diagnosis of multiple sclerosis who had received interferon beta1-b for eleven months was visited in MS clinic of our hospital because of icter and fatigue. Laboratory test...
Exposure to increased pressure or hyperbaric oxygen suppresses interferon-gamma secretion in whole blood cultures of healthy humans
Analysis of Variance Atmospheric Pressure CD4-Positive T-Lymphocytes Double-Blind Method Hematocrit
2009/6/5
This study examines the effects of hyperoxia, increased atmospheric pressure, and hyperbaric oxygen on cytokine synthesis. Five healthy volunteers were exposed to 90 min of room air, 100% oxygen, 10.5...
Sterile Corneal Ulcer and Sjögren’s Syndrome Associated with Long-Term Interferon alpha-2b Treatment in a Case of Multiple Myeloma
corneal ulcer interferon alpha-2b dry eyes Sjö gren’s syndrome immunosuppressant
2009/4/20
A 71-year-old Chinese male was referred for severe dry eyes who suffered from multiple corneal melting ulcers and underwent a long-term and high-dosage interferon alpha-2b (INFα-2b) treatment for mult...
Interferon-gamma liniment protects hairless mice against ultraviolet irradiation-induced skin damage
Interferon-gamma liniment protects hairless mice ultraviolet irradiation-induced skin damage
2009/3/3
Ultraviolet B (UVB) irradiation has been reported as one of causes of epidermal carcinoma and also one of immunosuppressive inducers associated with an up-regulated production of T helper (Th) 2-typ...
Inhibition of chlamydia trachomatis growth by human interferon-α：mechanisms and synergistic effect with interferon-γ and tumor necrosis factor-α
chlamydia trachomatis growth human interferon-α synergistic effect interferon-γ and tumor necrosis factor-α
2009/3/3
We have evaluated the effect of natural human interferon (IFN)-α on the growth of chlamydia trachomatis in human epithelial cells in vitro and revealed that IFN-α has reduced both growth and infecti...
Repeated regression of pulmonary metastases from renal cell carcinoma after treatment using different interferon-alpha preparations
pulmonary metastases renal cell carcinoma interferon-alpha preparations
2009/3/2
A 49-year-old man with pulmonary metastasis from renal cell carcinoma (RCC) was treated with recombinant IFN-α2b (Intron A®). A complete response was achieved within 4 months and thereafter pers...
Antitumor effects of a combination of interferon-alpha and sorafenib on human renal carcinoma cell lines
interferon-alpha sorafenib human renal carcinoma cell lines
2009/3/2
To support the role of interferon (IFN)-α and sorafenib combination therapy against renal cell carcinoma (RCC), the effects of IFN-α and sorafenib on tumor growth, vascular endothelial growth factor...
A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease
Nonsurgical therapy intralesional IFN-a-2B
2009/2/18
Intralesional therapy is a less invasive method for the treatment of Peyronie's disease. The objective of this study was to evaluate intralesional injections of interferon alpha 2B (IFN-alpha-2B) ...
Direct and indirect effects of murine interleukin-2, gamma interferon, and tumor necrosis factor on testosterone synthesis in mouse Leydig cells
murine interleukin-2 gamma interferon tumor necrosis factor testosterone synthesis
2009/2/11
It was recently observed that treatment of patients with a high dosage of human interleukin (IL-2) resulted in suppression of plasma concentrations of testosterone. A murine model was developed to a...
The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro
Tumor necrosis factor interleukin-1 interferon human sperm motility
2009/2/10
Whether cytokines present in human peritoneal fluid reduce sperm motility, and thus contribute to infertility, is investigated. The human recombinant cytokines, tumor necrosis factor-alpha, interl...