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南京农业大学农学院《Nature Communications》发表万建民院士团队“Genome-Wide association studies identify OsWRKY53 as s key regulator of salt tolerance in rice”（图）
万建民 基因 分子机制 蛋白
2023/10/28
盐碱胁迫影响水稻的生长发育、存活率与最终产量。水稻耐盐碱是由多基因控制的复杂性状。研究水稻应对盐碱胁迫的关键基因及其调控网络，对于培育耐盐碱水稻品种具有重要科学意义和应用价值。2023年6月16日，国际著名期刊Nature Communications发表了万建民院士团队在水稻耐盐碱研究上的新进展。
Optimized Homomorphic Encryption Solution for Secure Genome-Wide Association Studies
implementation public-key cryptography RNS variant of approximate homomorphic encryption genome-wide associate studies
2019/2/28
Genome-Wide Association Studies (GWAS) refer to observational studies of a genome-wide set of genetic variants across many individuals to see if any genetic variants are associated with a certain trai...
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies
cobalamin c.776G>C genetic association studies
2018/11/20
Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20–25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is r...
Identification of loci affecting teat number by genome-wide association studies on three pig populations
Genome-wide Association Study Imputation Meta-analysis Pig Teat Number
2017/3/7
Identification of loci affecting teat number by genome-wide association studies on three pig populations.
FACILITATING PHARMACOGENETIC ASSOCIATION STUDIES USING AN EXTENSIBLE GENOTYPE INFORMATION MANAGEMENT SYSTEM
Large-scale genome Clinical Pharmacology
2015/5/27
Large-scale genome data projects employing automated, high-throughput techniques have led to a deluge of genomic data that necessitate robust informatic solutions. COBRA-DB is an integrated web-based ...
Stories and Challenges of Genome Wide Association Studies in Livestock — A Review
QTL Livestock Genome-wide Association
2016/5/18
Undoubtedly livestock is one of the major contributors to the economy of any country. The economic value of livestock includes meat, dairy products, fiber, fertilizer etc. Understanding and identifyin...
Genome Wide Association Studies Using Multiple-lactation Breeding Value in Holsteins
Single Nucleotide Polymorphism Milk Production Traits Lactation, Holstein
2016/5/18
A genome wide association study was conducted using estimated breeding value (EBV) for milk production traits from 1st to 4th lactation. Significant single nucleotide polymorphism (SNP) markers were s...
Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium
arachidonic acid genome-wide association meta-analysis phospholipid trans fatty acids
2018/12/20
Background: Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent i...
Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium
arachidonic acid genome-wide association meta-analysis phospholipid trans fatty acids
2018/12/20
Background: Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent i...
Efficient Algorithms for Multivariate Linear Mixed Models in Genome-wide Association Studies
Efficient Algorithms Multivariate Linear Mixed Models Genome-wide Association Studies
2013/6/17
Multivariate linear mixed models (mvLMMs) have been widely used in many areas of genetics, and have attracted considerable recent interest in genome-wide association studies (GWASs). However, existing...
Replicability analysis for Genome-wide Association studies
Replicability analysis Genome-wide Association studies
2012/11/22
The paramount importance of replicating associations is well recognized in the genome-wide associaton (GWA) research community, yet methods for assessing replicability of associations are scarce. Publ...
Bayesian Analysis of Multiway Tables in Association Studies: A Model Comparison Approach
Bayesian Analysis Multiway Tables Association Studies Model Comparison Approach
2012/9/17
We consider the problem of statistical inference on unknown quantities structured as a multiway table. We show that such multiway tables are naturally formed by arranging regression coecients in comp...
Integrated analysis of variants and pathways in genome-wide association studies using polygenic models of disease
Integrated analysis of variants pathways genome-wide association studies polygenic models of disease
2012/9/18
Many common diseases are highly polygenic, modulated by a large number genetic factors with small effects on suscep-tibility to disease. These small effects are difficult to map reliably in genetic as...
Simultaneous SNP identification in association studies with missing data
Hierarchical models Bayes models Gibbs sampling genome-wide association.
2012/9/18
Association testing aims to discover the underlying relationship between genotypes (usually Single Nucleotide Polymorphisms, or SNPs) and phenotypes(attributes, or traits). The typically large data se...
New international research defends genome-wide association studies
genome-wide genetic variants
2014/7/17
Since 2005, genome-wide association studies (GWAS) have successfully identified thousands of genes responsible for common human diseases.