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在真核生物中，基因组DNA与组蛋白结合形成核小体单元，进而压缩染色质。染色质是基因调控的关键平台，所有与DNA相关的生命活动都和染色质密切相关。macroH2A作为组蛋白H2A分子量最大的变体，以其独特的linker和macro结构域，在X染色体失活、胚胎发育、细胞代谢及肿瘤发生等多个过程中发挥重要调控作用。组蛋白伴侣FACT（Facilitates Chromatin Transcription...
内蒙古自治区细胞分子调控重点实验室那顺布和课题组揭示组蛋白分子伴侣FACT调控染色质状态及基因转录的分子机制（图）
那顺布和 组蛋白 分子伴侣 染色质 基因转录 Journal of Biological Chemistry
2024/4/29
近日，内蒙古细胞分子调控重点实验室那顺布和课题组揭示了组蛋白分子伴侣FACT复合物调控全基因组范围内基因表达的分子机制。研究成果以“Transcriptional Regulation of FACT Involves Coordination of Chromatin Accessibility and CTCF Binding”为题发表在Journal of Biological Chemis...
泛素化修饰分化FACT调控染色质的分子机制（图）
泛素化修饰 分化FACT 染色质 分子机制
2023/1/6
在真核生命中，遗传信息载体DNA分子被一类特殊的蛋白-组蛋白（histone）有序地组织起来，逐级形成核小体（nucleosome）、染色质纤维（chromatin fiber）、染色质环（chromatin loop）、染色质TAD等关键中间结构，最终组装成具有复杂拓扑结构的染色质，将DNA层层包裹。所有与DNA有关的生命活动（比如DNA复制、修复、重组、基因转录等）都需要将这层层被包裹的DNA...
研究发现染转录辅助因子FACT的独特双重功能（图）
转录辅助因子 FACT 双重功能
2018/8/15
中国科学院物理研究所/北京凝聚态物理国家研究中心软物质物理重点实验室从2002年开始逐步建立起以磁镊力谱和荧光光谱为主的单分子研究体系，在DNA凝聚（JACS 2006，PRL 2012）、DNA与抗癌药物作用（NAR 2009, PRE 2015）、端粒四联体DNA折叠（JACS 2013）以及DNA解旋酶分子机理（EMBOJ 2008，NAR 2015，PRL 2016）等多个课题中取得了系列...
单分子力谱指纹揭示转录辅助因子FACT的双面性
单分子力谱指纹 转录辅助因子FACT
2018/8/17
两句耳熟能详的俗语“龙生龙，凤生凤”和“龙生九子各不相同”道出了生物遗传现象中两个关键的特点：相似性和特异性。人类基因组精确测序显示人类基因的差异很小（<0.3%），这解释了遗传相似性的来源；另一方面，基因被一类称为组蛋白的生物大分子通过层层组装形成高度有序的染色质结构，受重塑因子、组装因子、组蛋白和DNA的化学修饰以及组蛋白变体等多种因素影响，导致了遗传的特异性。单分子操纵技术是研究染色质动态调...
Efficient Compilers for After-the-Fact Leakage: from CPA to CCA-2 secure PKE to AKE
After-the-Fact leakage bounded memory leakage split-state
2017/5/25
The goal of leakage-resilient cryptography is to construct cryptographic algorithms that are secure even if the adversary obtains side-channel information from the real world implementation of these a...
On October 28, the National Science Foundation (NSF) announced in the Federal Register the Notice of Availability and Notice of Public Meetings for the Draft Environmental Impact Statem...
On May 23, the National Science Foundation (NSF) announced in the Federal Register the beginning of an environmental impact statement (EIS) process to evaluate potential environmental impact...
Modelling After-the-fact Leakage for Key Exchange
key exchange protocols public-key side-channel attacks
2016/1/25
Security models for two-party authenticated key exchange (AKE) protocols have developed over time
to prove the security of AKE protocols even when the adversary learns certain secret values. In this ...
Continuous After-the-fact Leakage-Resilient Key Exchange (full version)
leakage resilience key exchange continuous leakage
2016/1/23
Security models for two-party authenticated key exchange (AKE) protocols have developed over time to provide security even when the adversary learns certain secret keys. In this work, we advance the ...
On Continuous After-the-Fact Leakage-Resilient Key Exchange
Leakage-resilient cryptography Cryptographic protocols Key exchange
2016/1/5
Side-channel attacks are severe type of attack against implementation of cryptographic
primitives. Leakage-resilient cryptography is a new theoretical approach to formally address
the problem of sid...
Continuous After-the-fact Leakage-Resilient eCK-secure Key Exchange
key exchange protocols side-channel attacks leakage-resilience
2015/12/31
Security models for two-party authenticated key exchange (AKE) protocols have developed over
time to capture the security of AKE protocols even when the adversary learns certain secret values.
Incre...
Bird’s Eye View to Indonesian Mass Conflict:Revisiting the Fact of Self-Organized Criticality
social clashes social conflict and violence power law distribution Richardson’s Law self-organized criticality
2015/7/29
The paper statistically observed the recorded data of the series of social clashes and violence in Ambon, Indonesia in the period of social conflict between 1999-2004. The scaling laws are revealed an...
The Fact of Ignorance Revisiting the Socratic Method as a Tool for Teaching Critical Thinking
critical thinking Socratic method pharmacy education
2018/7/10
Critical thinking, while highly valued as an ability of health care providers, remains a skill that many educators find difficult to teach. This review provides an analysis examining why current metho...
Involving young workers in occupational safety and health (OSH) is a powerful tool to help strengthen workplace safety culture and performance. Getting young people to buy in to the safety culture of ...