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Effect of Iron-Mediated Oxidative Stress on Insulin Resistance Through the Forkhead Box-Containing Protein O Subfamily-1 (FOXO-1) Pathway in Chronic Hepatitis C
Chronic Hepatitis C Gluconeogenesis Insulin Resistance Iron Metabolism Oxidative Stress
2013/1/29
Aims: Chronic hepatitis C virus (HCV) infection is often associated with glucose metabolic disorders and iron overload. It has recently been shown that reactive oxygen species (ROS) increase gluconeog...
Myocardial insulin resistance does not always parallel skeletal muscle and whole body insulin resistance: A mini review —Myocardial Insulin Resistance
Insulin Resistance Myocardial Insulin Resistance Coronary Artery Disease
2013/1/28
Insulin resistance (IR) is recognized to be of critical importance in a variety of metabolic diseases and coronary artery disease (CAD). Impaired skeletal muscle glucose utilization (SMGU) plays an im...
Cord Plasma Concentrations of Visfatin, Adiponectin and Insulin in Healthy Term Neonates: Positive Correlation with Birthweight
adiponectin visfatin insulin birthweight
2009/10/26
Objective: The aims of this study were to examine the relationships between adiponectin, insulin, visfatin and weight at birth in healthy term infants. Design and methods: Anthropometric parameters in...
An Angiotensin II (Ang II) Type 1 Receptor Blocker, Telmisartan, Improves Insulin Resistance in KK-Ay Diabetic Mice
telmisartan insulin resistance hypertension diabetes PPAR-γ
2009/4/20
Metabolic syndrome is strongly associated with insulin resistance and consists of a constellation of factors such as hypertension and hyperlipidemia that raise the risk for cardiovascular diseases and...
Comparative study of insulin-mimetic activity of vanadium and zinc complexes
vanadyl(IV) zinc(II) insulin-mimetic effect type 1 diabetes mellitus
2009/4/1
In recent years, some metal ions and their complexes have been found to treat diabetes mellitus (DM) in not only experimental animals but also humans. Among them, vanadyl(IV) and zinc(II) ions as well...
Evaluation of the insulin-like activity of the vanadium（IV, V）-hydroxamic acid complexes using isolated rat adipocytes
insulin-like activity vanadium（IV, V）-hydroxamic acid complexes isolated rat adipocytes
2009/4/1
We synthesized a 1 : 2 complex between the vanadyl(IV)or vanadate(V)ion and benzohydroxamic acid (BHA), and assessed their insulin-like activity in terms of the inhibitory effects on free fatty acid r...
Oxovanadium（IV）and（V）Complexes with 3-Hydroxy-4（1H）-pyridinones and 1-Hydroxy-2(1H)-pyrimidinones — Synthesis, Structural Characteristics, and Their Insulin-mimetic Activities
3-hydroxy-4(1H)-pyridinone 1-hydroxy-2(1H)-pyrimidinone oxovanadium complex STZ-rat
2009/3/23
Five kinds of N-substituted 3-hydroxy-2-methyl-4(1H)-pyridinones, and three kinds of 1-hydroxy-2(1H)-pyrimidinones were synthesized. Treatment of 3-hydroxy-4(1H)-pyridinones with VO(acac)2 in CH3OH ex...
Tasting sweet food elicits insulin release prior to increasing plasma glucose levels, known as cephalic phase insulin release (CPIR). The characteristic of CPIR is that plasma insulin secretion occu...
Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion
Exoc3l protein exocyst subunit Sec6 insulin secretion
2009/3/2
The exocyst is an octameric complex involved in docking or tethering of secretory vesicles to fusion sites of the plasma membrane. Sec6 is the core subunit of the exocyst complex. Here we identify an ...