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近日,中南大学基础医学院肿瘤研究所研究员陶永光团队与湘雅医院刘双研究员和肖德胜团队在国际肿瘤学期刊Molecular Cancer(IF=41.444)发表了题为“The chromatin‑associated RNAs in gene regulation and cancer(在基因表达和癌症中的染色质相关RNA)”的综述。肖德胜教授、刘双研究员和陶永光研究员为本论文的共同通讯作...
近年来,CAR-T疗法治疗血液源性肿瘤效果显著,然而在针对实体瘤的临床研究中却遭遇重大挑战。目前CAR-T均为靶点激活杀伤,而肿瘤靶点通常也在正常组织低表达,进而产生“on-target, off-tumor”现象、诱生炎症因子风暴、中枢神经毒性等,给CAR-T治疗带来严重的安全隐患。肿瘤细胞的异质性进一步导致靶点激活杀伤有效性受到挑战。即目前的靶点激活杀伤的CAR-T技术在在治疗实体瘤中,安全性...
As tumors grow within an organ, they also release cells that enter the bloodstream. These cells can travel to other organs, seeding new tumors called metastases.
Whenever organic matter is burned, such as in a wildfire, a power plant, a car’s exhaust, or in daily cooking, the combustion releases polycyclic aromatic hydrocarbons (PAHs) — a class of pollutants t...
2020年12月4日,基础医学院病理学系韩博教授课题组最新研究成果“KIF15-mediated stabilization of AR and AR-V7 contributes to enzalutamide resistance in prostate cancer”(KIF15介导的ARAR-V7蛋白稳定性促进前列腺癌细胞对恩杂鲁胺耐药)在国际权威肿瘤学期刊Cancer Research...
近日,亚太地区规模最大的英文科技出版公司World Scientific出版了我校肿瘤干细胞与转化医学重点实验室主任邓锡云教授、湖南省肿瘤医院唐发清教授及俄亥俄大学Thomas Rosol教授共同主编的英文专著《Triple-Negative Breast Cancer》。
2020年3月19日,河南大学生命科学学院王彦明教授课题组及合作者在肿瘤转移领域取得重要进展,在国际上首次揭示组蛋白瓜氨酸化可在肿瘤细胞中解聚染色体并导致细胞外染色质丝的形成。而催化瓜氨酸化并在肿瘤组织中高表达的蛋白质肽基精氨酸脱氨酶4(PAD4)对促进肿瘤生长及转移发挥着重要作用。该研究成果以“Endogenous PAD4 in Breast Cancer Cells Mediates Can...
近日,国际著名肿瘤学期刊杂志Molecular Cancer(一区,IF:10.679)在线发表了江苏省肿瘤生物治疗重点实验室郑骏年教授和白津教授团队的综述“Functional roles of circular RNAs during epithelial-to-mesenchymal transition.”这是该团队继2019年在PNAS(一区,IF:9.58)发表研究论文后取得的又一项成...
近期,国际知名学术期刊、美国癌症协会会刊《Cancer Research》在线发表了实验室与天津医科大学医学院、上海交通大学医学院有关“肺癌肿瘤代谢调控研究”的合作研究成果:“PAK4 phosphorylates fumarase and blocks TGF-β-induced cell growth arrest in lung cancer cells”。研究阐明了转化生长因子β(TGF-...
2018年11月3日,我校附属第一医院病理科柯尊富主任医师肺癌研究团队在Clinical Cancer Research (IF 2017=10.19)期刊上发表了研究性论文Development and validation of a novel signature to predict overall survival in “driver-gene-negative” lung adenoc...
Applications for this meeting must be submitted by May 20, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be st...
The sixth Gordon Conference on Stem Cells and Cancer will focus on how stem cell aging influences the initiation and progression of cancer. Aging leads to progressive impairments in stem cell function...
Chronic pancreatitis, an inflammatory disease of the exocrine pancreas, has been reported to be a major risk factor for the development of pancreatic ductal adenocarcinoma. Evidence from pre-clinical ...
It is increasingly evident that inequalities exist for Indigenous people with cancer. Incidence for all cancers combined is similar to or lower than that of non-Indigenous people, but incidence of c...
Although efforts to encourage presentation with early signs of cancer has had some impact in down-staging disease at diagnosis, notably in breast cancer and melanoma, assertive, physician-initiated ...

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