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Autoradiographic localization of tritium-labeled dihydrotestosterone in human vas deferens
Autoradiographic localization tritium-labeled dihydrotestosterone human
2009/2/23
The human vas deferens was examined autoradiographically for the presence and distribution of androgen receptors. Samples of vas deferens from the region proximal to the testis and the region at the...
Comparison of Prostatic Response to Pituitary Grafts in Castrate Rats Treated with Testosterone or Dihydrotestosterone
prostate prolactin testosterone dihydrotestosterone
2009/2/19
To understand further the effect of prolactin (PRL) on prostatic growth, the present study was undertaken to determine if the augmentation of testosterone (T)-stimulated growth by PRL is mediated ...
Serum dihydrotestosterone and testosterone concentrations in human immunodeficiency virus-infected men with and without weight loss
estosterone DHT AIDS wasting HIV-associated
2009/2/18
Weight loss is an important determinant of disease outcome in human immunodeficiency virus (HIV)-infected men. Others have suggested that a defect in dihydrotestosterone (DHT) generation contribut...
Estradiol and high-dose dihydrotestosterone treatment causes changes in cynomolgus monkey prostate volume and histology identical to those caused by testosterone alone
Male transrectal ultrasonography androgens estrogens
2009/2/18
To evaluate the effects of testosterone (T), dihydrotestosterone (DHT), and estradiol (E2) on the regulation of prostate growth and tissue composition, the following study was conducted in a nonhuma...
Can spermatogenesis be maintained quantitatively in intact adult rats with exogenously administered dihydrotestosterone?
spermatogenesis adult rats with dihydrotestosterone
2009/2/12
It is well established that testosterone (T) is required to maintain spermatogenesis in the mammalian testis, presumably acting through a receptor mechanism, as elsewhere. It is puzzling, however,...
Specific regulatory actions of dihydrotestosterone and estradiol on the dynamics of FSH secretion and clearance in humans
Sex steroids pulsatile hormone episodic deconvolution
2009/2/7
The authors investigated immunoactive and bioactive follicle-stimulating hormone (FSH) secretion and clearance in six healthy young men during steady-state infusions of vehicle (basal, B, 28 hours),...
Effect of 5alpha-dihydrotestosterone implants on the fertility of male rats treated with tamoxifen
5alpha-dihydrotestosterone implants fertility male rats tamoxifen
2008/12/25
In adult male rats, tamoxifen (TAM) reduces circulating levels of luteinizing hormone (LH) and testosterone (T) with no effect on follicle-stimulating hormone (FSH) and prolactin (PRL). It reduces t...
Changes in Testosterone and Dihydrotestosterone Levels in Male Rat Accessory Sex Organs, Serum, and Seminal Fluid After Castration：Establishment of a New Highly Sensitive Simultaneous Androgen Measurement Method
LC-MS/MS hormone prostate seminal vesicles
2008/12/23
It is known that abnormal androgen dynamics in the tissues is a cause of androgen-dependent disorders. Investigation of tissue androgen levels could provide a clue to the elucidation of disorders....
Receptor Isoform and Ligand-Specific Modulation of Dihydrotestosterone-Induced Prostate Specific Antigen Gene Expression and Prostate Tumor Cell Growth by Estrogens
Androgen receptor androgens estrogen receptor
2008/12/23
Androgens via the androgen receptor (AR) play crucial roles in prostate physiology and pathophysiology. These androgen actions can be either inhibited or potentiated by estrogens. The mechanisms of ...
Androgen-Induced Prostate-Specific Antigen Gene Expression Is Mediated via Dihydrotestosterone in LNCaP Cells
5-Reductase isozymes testosterone prostatic tumor cells
2008/12/19
Prostate cancer is a leading cause of cancer death in American males. Androgens play an essential role in prostate development, growth and pathogenesis of benign prostate hyperplasia, and prostate c...
Cognitive Changes Associated With Supplementation of Testosterone or Dihydrotestosterone in Mildly Hypogonadal Men：A Preliminary Report
Memory gel androgens cognition spatial
2008/12/19
This study prospectively examined changes in cognition in hypogonadal men given testosterone (T) or older hypogonadal men given dihydrotestosterone (DHT) gel. A battery of cognitive tests assessing ...
Serum Androgen Bioactivity During 5-Dihydrotestosterone Treatment in Elderly Men
Androgen decline bioassay DHT
2008/12/16
The androgens used in the treatment of age-related androgen decline have different bioactivities that cannot be evaluated with conventional detection methods for serum steroids. We have recently devel...