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Increased expression of a 68-kDa protein in the corpus cavernosum of some men with erectile dysfunction
Erectile dysfunction cavernous body gel electrophoresis structural proteins
2009/2/13
Erectile dysfunction (ED) may be caused by abnormalities of intracavernous penile structures. In order to investigate whether specific proteins could be identified that might be related to ED, the c...
Enhanced pharmacological testing in patients with erectile dysfunction
Enhanced pharmacological testing patients erectile dysfunction
2009/2/13
This study was designed to evaluate the practical use of the combination of a low-dose intracavernous injection test (ICI) and visual erotic stimulation (VES) in the assessment of patients with er...
Treatment of idiopathic erectile dysfunction in men with the opiate antagonist naltrexone--a double-blind study
Naltrexone idiopathic erectile dysfunction doubleblind
2009/2/12
Opiate antagonists can indirectly stimulate the secretion of luteinizing hormone (LH) and testosterone, as well as sexual functions in animals and humans. We therefore treated 20 otherwise healthy m...
Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors
Hypogonadism medication/lifestyle modifications
2008/12/29
The objective of this study was to determine the efficacy and safety of sildenafil in patients with erectile dysfunction (ED) and associated organic risk factors in a multispecialty clinic. Patien...
Penile Oxygen Saturation in the Flaccid and Erect Penis in Men With and Without Erectile Dysfunction
Corporal oxygen saturation tissue oximeter
2008/12/24
It is believed that a chronic state of corporal oxygen desaturation or hypoxemia secondary to the loss of nocturnal erections is a fundamental pathophysiological cause of erectile dysfunction (ED...
Pesticides and Polychlorinated Biphenyls as Potential Risk Factors for Erectile Dysfunction
Erectile function environment organochlorines plasma epidemiology
2008/12/24
While it is biologically plausible that environmental chemicals such as pesticides and polychlorinated biphenyls (PCBs) with suspected hormone disrupting properties may have an impact on risk of ere...
Factors Affecting the Increased Prevalence of Erectile Dysfunction in Greek Hypertensive Compared With Normotensive Subjects
Erectile function hypertension hypertension severity hypertension treatment age
2008/12/24
Arterial hypertension is considered a risk factor for erectile dysfunction. The aim of the study was to evaluate the prevalence of erectile dysfunction in hypertensive compared with normotensi...
Role of Oxidative Stress in the Pathophysiological Mechanism of Erectile Dysfunction
Oxidative Stress Pathophysiological Mechanism Erectile Dysfunction
2008/12/24
Erectile dysfunction (ED) is defined as the inability to achieve or maintain erections sufficient for satisfactory sexual intercourse (NIH Consensus Conference, 1993). It is estimated that the pre...
Vardenafil in Patients With Erectile Dysfunction：Achieving Treatment Optimization
Impotence drug therapy clinical trial phosphodiesterase inhibitor cumulative probability
2008/12/23
This post hoc analysis of data from a multicenter, randomized, double-blind study determined how many attempts were needed to record at least 1 successful penetration and maintenance of erection l...
Tadalafil Improved Erectile Function at Twenty-Four and Thirty-Six Hours After Dosing in Men With Erectile Dysfunction：US Trial
Phosphodiesterase inhibitors efficacy successful sexual intercourse Sexual Encounter Profile (SEP) diary
2008/12/23
In a previous study assessing tadalafil for the treatment of erectile dysfunction (ED), tadalafil 20 mg was shown to improve erectile function for up to 36 hours vs placebo. This study sought to demon...
Erectile Dysfunction in Smokers：A Penile Dynamic and Vascular Study
Smoking impotence color duplex pharmacocavernosometry veno-occlusion
2008/12/22
In this study, we aimed to determine the hemodynamic mechanisms through which cigarette smoking, as an independent risk factor, induces erectile dysfunction (ED). We performed a standard ED evalua...
Oxidative Stress and Antioxidant Therapy：Their Impact in Diabetes-Associated Erectile Dysfunction
Impotence vitamin E sildenafil nitric oxide phosphodiesterase type
2008/12/22
Oxidative stress is believed to affect the development of diabetic-associated vasculopathy, endothelial dysfunction, and neuropathy within erectile tissue. Our hypothesis is that, given adequate con...
Glu298Asp Endothelial Nitric Oxide Synthase Polymorphism Is a Risk Factor for Erectile Dysfunction in the Mexican Mestizo Population
Angiotensin-converting enzyme endothelial dysfunction impotence
2008/12/22
Penile erection depends on the balanced action between antagonist vasoactive molecules such as nitric oxide (NO) and angiotensin. Endothelial nitric oxide synthase (eNOS) and angiotensin-convertin...
Cardiovascular Parameter Changes in Patients With Erectile Dysfunction Using Pde-5 Inhibitors：A Study With Sildenafil and Vardenafil
hypotensive effect side effect crossover study
2008/12/22
Sildenafil is the most prescribed oral agent for patients with erectile dysfunction (ED). Vardenafil is a new phosphodiesterase type 5 (Pde-5) inhibitor that was approved by the US Food and Drug Adm...
Molecular Biology and Pharmacology of PDE-5—Inhibitor Therapy for Erectile Dysfunction
Molecular Biology Pharmacology PDE-5—Inhibitor Therapy Erectile Dysfunction
2008/12/19
In light of newly emerging selective phosphodiesterase type 5 (PDE-5) inhibitors, it is necessary to understand the basic biochemical and pharmacological principles of PDE-5 inhibitor action (Corbin a...