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Evaluation of oxidative DNA damage in human sperm and its association with male infertility
8-Hydroxydeoxyguanosine spermatozoa infertility
2009/2/18
Recently, there is increasing evidence suggesting that oxidative sperm DNA damage is closely associated with impaired sperm function and male infertility. 8-Hydroxydeoxyguanosine (8-OHdG) is consi...
In vitro sperm-binding assay to distinguish differences in populations of human sperm or damage to sperm resulting from cryopreservation
Sperm quality fresh versus frozen semen
2009/2/18
Annually, >1.3 million men are members of couples seeking help because of infertility. Semen from many of these men contains reasonable numbers of motile and normal sperm, but for a subset of indivi...
Studies on sperm chromatin structure alterations and cytogenetic damage of mouse sperm following in vitro incubation. Studies on in vitro-incubated mouse sperm
sperm chromatin structure alterations cytogenetic damage of mouse sperm
2009/2/12
Mouse epididymal sperm incubated in Tyrode's T6 fertilization media were analyzed over time for chromosome damage by two methods. First, cytogenetic analysis was done on paternal pronuclei metapha...
Evidence for increased lipid peroxidative damage and loss of superoxide dismutase activity as a mode of sublethal cryodamage to human sperm during cryopreservation
superoxide dismutase activity sublethal cryodamage human sperm cryopreservation
2009/2/10
Cryopreservation of human sperm, now generally required in donor insemination programs, adversely affects the sperm in terms of standard sperm evaluation parameters and fertilizing ability. The fr...
An immunochemical assay to detect DNA damage in bovine sperm
immunochemical assay DNA damage bovine sperm
2008/12/25
An immunochemical assay has been developed to detect oxidative damage in bovine sperm DNA. Sperm DNA contains a large amount of oxidative damage as a result of exposure to exogenous agents, but dama...
Damage to Chromosomes and DNA of Rhesus Monkey Sperm Following Cryopreservation
Macaque spermatozoa ICSI
2008/12/24
Fresh and frozen-thawed rhesus monkey sperm were analyzed for DNA damage using the comet assay and for chromosome damage by cytogenetic analysis after intracytoplasmic sperm injection (ICSI) into...
DNA Damage in Bovine Sperm Does Not Block Fertilization and Early Embryonic Development But Induces Apoptosis After the First Cleavages
Mitotic spindles blastocyst ICSI
2008/12/23
The main goal of this study was to investigate whether and at what level damage of paternal DNA influences fertilization of oocytes and early embryonic development. We hypothesized that posttesticul...
Infertile Men With Varicocele Show a High Relative Proportion of Sperm Cells With Intense Nuclear Damage Level, Evidenced by the Sperm Chromatin Dispersion Test
Human sperm DNA fragmentation
2008/12/23
The frequency of sperm cells with fragmented DNA was studied in a group of 18 infertile patients with varicocele and compared with those obtained in a group of 51 normozoospermic patients, 103 patie...
Nickel-Induced Oxidative Stress in Testis of Mice：Evidence of DNA Damage and Genotoxic Effects
Nickel chloride oxidative damage apoptosis abnormal sperms dominant lethal mutations
2008/12/22
Oxidative stress (OS) mechanisms are speculated to play a significant role in nickel-induced toxic effects and their carcinogenic potency. Although nickel-induced oxidative damage in somatic tissues...
Spermiogenic Germ Cell Phase–Specific DNA Damage Following Cyclophosphamide Exposure
Sperm comet assay chromatin remodeling susceptibility toxicology
2008/12/22
The production of genetically competent spermatozoa is essential for normal embryo development. The chemotherapeutic drug cyclophosphamide creates cross-links and DNA strand breaks in many cell type...
Cryopreservation of Ram Semen Facilitates Sperm DNA Damage: Relationship Between Sperm Andrological Parameters and the Sperm Chromatin Structure Assay
Artificial insemination semen quality motility chlortetracycline viability SCSA
2008/12/22
We hypothesized that cryopreservation and incubation in conditions that mimic the female genital tract following insemination increases the susceptibility of ram sperm DNA to denaturation. Ram spe...
Detection of DNA damage in response to cooling injury in equine spermatozoa using single-cell gel electrophoresis
DNA damage equine spermatozoa single-cell gel electrophoresis
2008/12/1
Single-cell gel electrophoresis (SCGE), or comet assay, has the ability to detect damage at the single cell level and has not been reported for equine sperm. The ability to detect nuclear damage at ...