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In a clinical trial of 403 patients, Massachusetts General Brigham investigators found that 55 percent of those who received ketamine treatment experienced a sustained improvement in depressive sympto...
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
sepsis severe sepsis scoring system Sequential Organ Failure Assessment mortality
2014/11/28
Objectives Organ failure worsens outcome in sepsis. The Sequential Organ Failure Assessment (SOFA) score numerically quantifies the number and severity of failed organs. We examined the utility of the...
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
sepsis septic shock emergency medicine mortality
2014/11/28
Introduction Early structured resuscitation of severe sepsis has been suggested to improve short term mortality; however, no previous study has examined the long-term effect of this therapy. We sought...
Prospective External Validation of the Clinical Effectiveness of an Emergency Department-Based Early Goal-Directed Therapy Protocol for Severe Sepsis and Septic Shock
early goal-directed therapy emergency department resuscitation sepsis septic shock
2014/11/28
Objective: To determine the clinical effectiveness of implementing early goal-directed therapy (EGDT) as a routine protocol in the emergency department (ED). Methods: Prospective interventional study ...
Performance of the Mortality in emergency department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock
sepsis septic shock mortality emergency department MEDS score
2014/11/28
Objective The aim of the study was to test if the Mortality in Emergency Department Sepsis (MEDS) score accurately predicts death among emergency department (ED) patients with severe sepsis and septic...
Integrating Assertive Community Treatment and Illness Management and Recovery for Consumers with Severe Mental Illness
assertive community treatment illness management and recovery
2014/11/10
This study examined the integration of two evidence-based practices for adults with severe mental illness: Assertive community treatment (ACT) and illness management and recovery (IMR) with peer speci...
Parenthood and severe mental illness: Relationships with recovery
parent severe mental illness recovery
2014/11/10
Objective: Parenting is an important life domain for many people, but little research examines the parenting experience and its role in recovery for those with a severe mental illness (SMI).The curren...
Multidisciplinary Rehabilitation Programs for Moderate to Severe Traumatic Brain Injury in Adults
Multidisciplinary Rehabilitation Programs Moderate to Severe Traumatic Brain Injury in Adults
2013/12/10
This report is based on research conducted by the Minnesota Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville,MD (Contract No. 290...
Effectivity of One Session Charcoal Hemoperfusion Treatment in Severe Carbamazepine Poisoning
Carbamazepine Toxicity Hemoperfusion
2015/10/8
A carbamazepine intoxication with attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. We report a cas...
Severe Dysphagia After Inferior Alveolar Nerve Block Preceded By Cervical Botolinum Toxin Injection:A Case Report
Deglutition Disorders Anesthesia Local Botulinum Toxins Cervical Dystonia Side Effect
2015/10/8
A 39-year-old Iranian female patient who was a known case of primary cervical dystonia since 10 years ago presented to a private office for Dysport injection. The patients experienced severe dysphagia...
Ovarian Cyst Enlargement in a 14 Year Old Female with Persistent Ascities, Severe Hypothyroidism and Elevated Serum CA-125 Level
Ovarian cyst Hypothyroidism CA-125 Van Wyk and Grumbach syndrome
2015/9/25
A 14 year old female complained of abdominal pain and distention with vomiting. The physical exam showed thyroid enlargement and ascites. The imaging evaluation demonstrated a large ovarian cyst. Labo...
Predisposing factors for serum sodium disturbance in patients with severe traumatic brain injury (SBI)
Hyponatremia hypernatremia severe brain injury intensive care unit
2010/11/22
Disturbances in the plasma sodium level in patients with severe brain injury (SBI) is not a rare phenomenon and may cause adverse effects on prognosis and treatment outcomes. The knowledge of the prev...
Major clinical trial prompts call for change to treatment guidelines for severe malaria worldwide
clinical trial guidelines severe malaria worldwide
2011/1/5
The largest ever clinical trial in patients hospitalised with severe malaria has concluded that the drug artesunate should now be the preferred treatment for the disease in both children and adults ev...
Necrotizing Pancreatitis as an Unusual Cause of Severe Abdominal Pain during Pregnancy
Necrotizing pancreatitis Severe abdominal pain Pregnancy
2015/9/21
Acute pancreatitis is an uncommon cause of abdominal pain during pregnancy that may become severe and rarely progresses to a necrotizing form with a high maternofetal mortality even in young patients....
Adverse events associated with exchange transfusion and etiology of severe hyperbilirubinemia in near-term and term newborns
Hyperbilirubinemia, exchange transfusion newborn
2011/3/22
To assess clinical features, etiology, and complications in term and near-term newborns who received exchange transfusion. Materials and methods: Infants with >=35 gestational weeks admitted to our ne...