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Sphingosine 1-phosphate enhances excitability of sensory neurons through sphingosine 1-phosphate receptors 1 and/or 3
sphingosine 1-phosphate S1P excitability sensory neurons G protein-coupled receptors
2015/5/21
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that has proven to be an important signaling molecule both as an extracellular primary messenger and as an intracellular second messenger. Ext...
Complement Receptors
补体受体 Complement Receptors
2014/6/24
Complement receptors are membrane proteins expressed on the surface of immune cells.They interact specifically with complement factors leading to the removal of antigen from the circulation.
Immunohistochemical Expression of C-Erb-B2, Steroid Receptors and Cathepsin-D in Breast Carcinomas: A Clinicopathologic Trial
Breast carcioma cathepsin-D c-erb-B2
2009/6/29
Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operat...
Role of Prostaglandin D2 and Its Receptors in the Pathophysiology of Asthma
asthma CRTH2 DP eosinophils lipid mediators single nucleotide polymorphisms
2010/11/17
Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the ide...
Toll-Like Receptors and Airway Inflammation
airway inflammation bronchial epithelial cells innate immune
2010/11/17
The respiratory tract opens to the external environment at the oral side edge, and the other edge of the respiratory tract connects to the closed space (alveoli), and so to preserve the sterility in t...
Effects of KP-496, a Novel Dual Antagonist for Leukotriene D4 and Thromboxane A2 Receptors, on Contractions Induced by Various Agonists in the Guinea Pig Trachea
antagonist anti-asthmatic drugs asthma leukotriene D4 thromboxane A2
2010/11/19
KP-496 produced parallel rightward shifts of the LTD4 and U46619 concentration-response curves in a concentration-dependent manner. Schild plot analyses of the antagonistic activities of KP-496 demons...
Morphological Specifications of the Bird Schistosome Cercariae and Surface Carbohydrates as Receptors for Lectins
Bird Mannose
2010/4/12
Background: To determine the morphological specifications of the bird schistosomes cercaria from Lymnaea gedrosiana and to detect the surface carbohydrates as receptors for host lectins in the host-pa...
Pharmacological Interaction of Drugs with Immune Receptors: The p-i Concept
drug hypersensitivity hapten p-i concept prohapten T cells T-cell receptor
2010/11/18
Drug-induced hypersensitivity reactions have been explained by the hapten concept, according to which a small chemical compound is too small to be recognized by the immune system. Only after covalentl...
β2-Adrenergic receptors: Structure, regulation and signaling by partial and full agonists
β2-adrenergic receptor selective agonist agonist-specific conformation constitutively active receptor
2010/11/22
It is believed that G-protein-coupled receptors are the most promising target proteins for drug research. The β2-adrenergic receptor has been analyzed extensively in terms of its structure, regulation...
Human mast cell activation through Fc receptors and Toll-like receptors
adaptive immunity FcεRI FcγRI GeneChip innate immunity mast cell Toll-like receptor 4
2010/11/22
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...
The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR
Dopamine Receptors Gene Expression Lymphocytes Polymerase Chain Reaction
2010/2/8
There is interrelationship between the immune and nervous systems that is accomplished by the molecular mediators. Dopamine is one of the most important neurotransmitters. Five different dopamine rece...