搜索结果: 1-11 共查到“医学 cyclooxygenase-2”相关记录11条 . 查询时间(0.125 秒)
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
cyclooxygenase-2 COX-2 COX-1 prostaglandin E2 neuroinflammation blood-brain barrier ischemia stroke matrix metalloproteinase MMP-3 MMP-9 gelatinase B stromelysin-1 oxidative stress indomethacin cyclooxygenase-1 glutathione free radicals MRI
2015/7/29
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor necrosis factor-alp...
Cyclooxygenase inhibition in ischemic brain injury.
cyclooxygenase-2 ischemia stroke cerebral ischemia neuroinflammation excitotoxicity
2015/7/28
Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is ...
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
vitamin C cyclooxygenase-2 oxidative stress Alzheimer’s disease stroke reactive oxygen species neuroinflammation NSAIDs 8-isoprostanes prostaglandin E synthase
2015/8/3
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathop...
The effects of 3-benzoyl-1-methyl-4-phenyl-4 piperidinolhydrochloride (C1), indomethacin, nimesulide and rofecoxib on cyclooxygenase activities in carrageenan-induced paw edema model
3-benzoyl-1-methyl-4-phenyl-4-piperidinol-hydrochloride COX enzymes inflammation
2010/10/14
The aim of this study was to investigate the effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol-hydrochloride (C1), which is a structural and also non-classical isomer of bis Mannich base, bis (3-ar...
Selective cyclooxygenase-2 inhibition prevents bone resorption
Alveolar bone loss Anti-inflammatory agents,non-steroidal Cyclooxygenase inhibitors Periodontitis Radiography dental
2009/10/19
The aim of the present work was to evaluate the effect of a selective cyclooxygenase-2 (COX-2) inhibitor (meloxicam) on the alveolar bone loss progression in experimentally induced periodontitis. Fort...
Cyclooxygenase II:A Molecular Target for Colorectal Cancer Prevention and Treatment?
cyclooxygenase-2 (COX-2) microsomal prostaglandin E synthase-1 (mPGES-1) colorectal cancer chemoprevention COX-2 inhibitor
2009/7/15
PGE2 plays a key role in colon carcinogenesis. Evidence continues to accumulate that cyclooxygenase-2 (COX-2), an inducible COX isoform, represents a potential pharmacological target for the preventio...
Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer
vascular endothelial growth factor-C vascular endothelial growth factor receptor-3 cyclooxygenase-2 lymphagiogenesis lymph node metastasis
2009/4/29
To investigate the roles of VEGF-C, VEGFR-3 and cyclooxygenase-2 (COX-2) in tumor progression and lymph node metastasis. The expression of VEGF-C, VEGFR-3 and COX-2 were examined in 93 cases of surgic...
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells：involvement of the p38MAPK pathway
Cyclooxygenase-2 lysophosphatidylcholine cultured rat vascular smooth muscle cells
2009/3/2
Lysophosphatidylcholine (lysoPC) stimulates the release of prostaglandins (PGs) in various cells and tissues. Cyclooxygenase (COX)-2 has recently emerged as a key regulator of PG synthesis. We inves...
Evidence for a role of cyclooxygenase（prostaglandin synthetase）and prostaglandins in the sperm acrosome reaction and fertilization
spermatozoa fertilization acrosome reaction cyclooxygenase prostaglandin inhibitor
2009/2/23
Three cyclooxygenase (prostaglandin synthetase) inhibitors, indomethacin, phenylbutazone, and oxyphenbutazone, decreased fertilization in vitro when mixed with capacitated mouse spermatozoa before a...
The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways
human spermatozoa acrosome reaction arachidonic acid eicosanoids cyclooxygenase lipoxygenase
2009/2/11
The objective of this study was to determine whether the metabolism of arachidonic acid via the cyclooxygenase pathway, the lipoxygenase pathway, or both has a pivotal role in the human sperm acro...
17β-estradiol and progesterone upregulate cyclooxygenase-2 expression in the human gingival fibroblasts
Gingivitis COX-2 Immunocytochemistry
2010/4/6
Gingivitis is associated with 60-75% of all pregnancies and elevated levels of 17β-estradiol and progesterone is known to increase gingival inflammation and the proinflammatory prostaglandins in the h...