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Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by ...
Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi Sch...
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
An exhaustive analysis has been conducted of more than 12,000 distinct proteins present in an often aggressive and difficult to treat form of breast cancer, called triple-negative breast cancer.The re...
Given that cancer is driven by inherited and acquired defects in our genetic code, the ability to profile genes and their activities has the potential to impact substantially on the prevention and tre...
A large number of monoclonal antibodies (mAbs) are currently under investigation for the treatment of malignant diseases. To date, a significant amount of experimental and clinical research had bee...
UQ researcher Dr Kris Thurecht is developing new molecules to potentially improve the performance of cancer therapy by delivering drugs directly to cancers. Dr Thurecht was awarded a $90,000 UQ Founda...
Objectives. To investigate the pharmacists' role in providing targeted therapies to patients and its implications for pharmacy education. Methods. Nine pharmacy faculty members, 12 clinical pharmacis...
Until the early 1990s, human cancers were considered a morphologically heterogeneous population of cells. In 1997, Bonnet et al demonstrated that a small population of leukemia cells was able to diffe...
Translational research, in general, means to take knowledge from one area into a second. Traditional thought to represent transfer of knowledge from basic research into the clinic, translational resea...
Monoclonal antibodies have already established a secure position as a very promising strategy for anti-tumor therapeutics. High specificity and high affinity are attractive characteristics of antibodi...
Combined Cancer Therapy of Ultrasound and Drug Delivery.
UPTON, NY As part of an effort to make high-precision particle cancer therapy accessible to more patients, a physicist at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory has dev...
Caspase activation has been frequently viewed as synonymous with programmed cell death (PCcD); however, accumulating evidence showed that there existing caspase-independent PCcD pathways displaying m...
Breast cancer is the second most common cancer among women in the US after skin cancer. While early detection and improved therapy has led to an overall decline in breast cancer mortality, metastatic ...

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