搜索结果: 1-15 共查到“医学 ATM”相关记录19条 . 查询时间(0.093 秒)
印度桑贾伊·甘地医学研究生院在“Redox Biology”杂志发表了题为G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity的文章。G蛋白β5-atm复合物驱动扑热息痛肝毒性。该研究为Gβ5在肝脏中的新的、非G蛋白依赖的作用提供了一个可行的解释。G-β5在导致急性胰腺炎依赖性肝损伤的多种病理后遗症中处于关键节点...
拓扑异构酶抑制剂通过ATM/ATR和NF-κB途径上调乳腺癌细胞MICA/B 的表达
拓扑异构酶抑制剂 MHCⅠ类链相关分子A/B 毛细血管扩张性共济失调突变蛋白 毛细血管扩张性共济失调Rad3相关激酶 NF -&kappa B 乳腺肿瘤
2018/12/6
目的：分析常用化疗药物对免疫识别乳腺癌细胞重要的靶标主要组织相容性复合体Ⅰ类相关分子A和B（major histocompatibility complex class Ⅰ-related chain A and B，MICA/B）的影响，探讨其调节MICA/B表达的分子机制。方法：用荧光定量RT-PCR法检测化疗药物对乳腺癌细胞MICA和MICB mRNA表达的影响，流式细胞术检测化疗药物对MI...
p38MAPK对肿瘤细胞ATM、ATR和p53信号通路的影响
DNA损伤 细胞周期 肿瘤
2013/9/2
研究p38MAPK对细胞周期信号转导通路中重要蛋白激酶ATM、ATR、P53的影响并探讨其可能的机制。方法 采用人类结肠癌细胞株HT-29和肺癌细胞株SPAC-1进行研究，分别使用紫外线(UV)刺激和p38MAPK特异性抑制剂SB203580抑制肿瘤细胞中的p38MAPK，通过Western blot技术检测ATM、ATR、P53蛋白磷酸化情况，同时用real-time PCR技术检测细胞中相应基...
CO2 retention with minimal symptoms but severe dysfunction during wet simulated dives to 6.8 atm abs
exercise hyperbaric air chamber carbon dioxide cognitive behavior
2009/7/9
During wet dives in a hyperbaric chamber to 6.8 atm abs (690 kPa), air breathing subjects were experimentally exposed to external breathing resistance. Two of them were, unbeknownst to themselves, sev...
Cardiovascular responses to upright tilt in man during acute exposure to 3 atm abs air
cardiovascular hyperbaric cardiac output position
2009/7/8
To examine the effect of acute hyperbaric exposure on cardiovascular response to orthostasis, a passive 70 degrees head-up tilt (HUT) test was performed for 15 min in a simulated compressed-air hyperb...
人脑胶质瘤中ATM、ATR、Chk1和Chk2基因表达研究。
ATM基因与肿瘤细胞放射敏感性关系的研究进展
ATM基因 放射敏感性 放射治疗
2009/6/15
毛细血管扩张性共济失调症(ataxia telangiectasia, AT)患者临床表现为高放射敏感性，其中ATM(AT_mutated)基因扮演着极其重要的作用。本文综述了ATM基因的结构、作用机制以及与肿瘤细胞放射敏感性之间关系的研究进展。
ECG changes during the experimental human dive HYDRA 10 (71 atm/7,200 kPa)
saturation decompression hydrogen human
2009/6/9
Electrocardiogram (ECG) analysis was performed in three human divers during a 71 atm (7,200 kPa) saturation dive (COMEX HYDRA 10 experiment). The inhaled gas mixture was slightly hyperoxic; its compos...
Diurnal renal responses in man to water loading at sea level and 31 atm abs
hyperbaric renal hydration Diuresis Circadian Rhythm
2009/6/9
The hyperbaric environment causes a sustained diuresis accompanied by normal water intake and a decrease in insensible water loss. The maintained water intake may be necessary for the maintenance of w...
Doppler-echocardiography study of cardiac function during a 36 atm (3,650 kPa) human dive
saturation pulmonary cardiac output human
2009/6/8
To determine the influence of a saturation dive on cardiac function, Doppler-echocardiographic measurements were compared at sea level and during a 36 atm (3,650 kPa) He-O2 dive (gas density: 7 g/lite...
Effects of breathing air at 4 atm abs:evidence for a change in strategy
hyperbaric air breathing
2009/6/5
The effect of breathing air at 4 atm abs on two tasks was investigated. For the recognition memory task, subjects learned a list of symbols in anticipation of a recognition test. The second task was a...
Estimating Skin Respiration from Transcutaneous PO2/PCO2 at 1 and 2 atm abs on Normal and Inflamed Skin
Transcutaneous skin inflamed
2009/5/8
Abbot NC, Beck JS, Carnochan FM, Spence VA, James PB. Estimating Skin Respiration from Transcutaneous PO2/PCO2 at 1 and 2 atm abs on Normal and Inflamed Skin. J. Hyperbaric Med 1990; 5(2):91-102.
Transcutaneous Partial Pressure of Oxygen Measured in a Monoplace Hyperbaric Chamber at 1, 1.5, and 2 atm abs Oxygen
oxygen Chamber Monoplace Transcutaneous
2009/5/8
Hart GB, Meyer GW, Strauss MB, Messina VJ. Transcutaneous Partial Pressure of Oxygen Measured in a Monoplace Hyperbaric Chamber at 1, 1.5, and 2 atm abs Oxygen. J. Hyperbaric Med 1990; 5(4):223-229. ...
O2 pressures between 0.12 and 2.5 atm abs, circulatory function, and N2 elimination
rebreather decompression nitrogen elimination hypoxiaoxygen
2009/3/25
To study the effects of inhaled oxygen pressures on N2 elimination, 72, 2-h washouts were performed in 6 subjects at oxygen pressures of 0.12, 0.2, 1.0, 2.0, and 2.5 atm abs using a closed circuit sys...