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2017肌萎缩性侧索硬化症和相关运动神经元疾病戈登学术会议（The 2017 Gordon Research Conference on Amyotrophic Lateral Sclerosis (ALS) & Related Motor Neuron Diseases）
Amyotrophic Lateral Sclerosis (ALS) Related Motor Neuron Diseases
2017/1/14
The goal of this meeting is to provide a dynamic forum for the active exchange of new discoveries and research tools in the advancing field of motor neuron diseases. Motor neuron diseases are a family...
Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases are hereditary, a significant number of them are caused by mutations that affect proteins that bind RNA, a type of genetic materia...
叶酸代谢基因缺失对ALS线虫运动能力影响
肌萎缩侧索硬化症 超氧化物歧化酶1 叶酸
2014/10/11
了解5-甲酰四氢叶酸环连接酶（Y106G6E.4）、蛋氨酸合成酶（R03D7.1）和四氢叶酸脱氢酶（Dao-3）基因突变对肌萎缩侧索硬化症（ALS）秀丽隐杆线虫运动能力的影响。方法 通过与N2株系杂交获得单拷贝G85R：YFP雄虫，分别与VC2322（Y106G6E.4）、RB755（R03D7.1）和VC1197（Dao-3）突变株系回交，单线虫PCR法鉴定后代三突变基因纯合性，荧光鉴定超氧化物...
ALS小鼠脊髓组织GFAP蛋白赖氨酸的乙酰化修饰
胶质纤维酸性蛋白 乙酰化修饰 肌萎缩脊髓硬化症 液相二级质谱连用
2013/11/11
探讨肌萎缩脊髓硬化症(ALS)模型小鼠脊髓组织胶质纤维酸性蛋白(GFAP)中赖氨酸的乙酰化修饰。方法 对4个月左右的ALS模型小鼠进行麻醉处死，提取小鼠脊髓组织总蛋白，通过GFAP抗体和乙酰化抗体，运用免疫沉淀和免疫蛋白印迹技术鉴定GFAP蛋白的表达与GFAP蛋白赖氨酸的乙酰化修饰，通过液相二级质谱连用(LC-MS/MS)检测ALS模型小鼠脊髓组织中GFAP赖氨酸的乙酰化修饰位点。结果 免疫...
Early Exposure to Environmental Toxin Contributes to Neuronal Vulnerability and Axonal Pathology in a Model of Familial ALS
SOD1 ALS Neurotoxin Axonopathy NMJ Gliosis Toxicity
2013/1/30
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons. Sporadic ALS causa...