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Affinity of new anticancer agent, 7-trimethylsilyl-ethyl-10-amino-camptothecin, to membranes and HSA determined by fluorescence spectroscopy methods
camptothecin silatecan fluorescence anisotropy
2011/5/6
The application of fluorescence anisotropy measurements in determining the properties of camptothecin analogue 7-trimethylsilylethyl-10-amino-camptothecin – a promising anticancer agent – is described...
Deactivation rate of camptothecin determined by factor analysis of steady-state fluorescence and absorption spectra
camptothecin fluorescence absorption factor analysis
2011/4/28
Camptothecin is a fluorescent compound exhibiting strong anticancer properties. A serious limitation to clinical application of this compound is its hydrolysis, when biologically active lactone form c...