搜索结果: 1-4 共查到“神经生物学 Protein”相关记录4条 . 查询时间(0.13 秒)
Protein & Cell | 李丹/彭小忠/杨俊涛/苏昭铭发现SARS-CoV-2干扰应激颗粒稳态并促进蛋白病理性相变聚集 （图）
帕金森病 阿尔兹海默病 H1N1流感病毒 疱疹病毒
2022/9/15
应激条件下蛋白质通过相互作用发生液-液相分离（Liquid-liquid phase separation，LLPS）驱动应激颗粒（Stress granule，SG）的形成。SG中的关键致病蛋白TDP-43，FUS及hnRNPA1等的相分离调控紊乱与神经退行性疾病的发病机制密切相关。研究发现，多种病毒，如H1N1流感病毒、疱疹病毒等，在侵染宿主时能入侵中枢神经系统，引起蛋白稳态失调及炎症反应，并...
神经退行性疾病（阿尔兹海默症、亨廷顿舞蹈症、帕金森病、肌萎缩侧索硬化症等）为何出现特定脑区的典型神经细胞死亡是神经科学领域一直关注的重点。小动物模型如最常用的小鼠模型因与人类大脑结构差异巨大，绝大多数无法模拟神经退行性病人典型神经细胞死亡的病理特征，且在小鼠脑疾病中发挥作用的药物在临床实验中多以失败而告终。
Cloning and characterization of GUKHolder, a novel synaptically expressed protein that interacts with Discs -Large and SCRIBBLE at the Drosophila neuromuscular junction
Neurons spatial arrangement protein tumor protein complex enzyme
2014/12/11
Synaptic transmission between a neuron and its target is crucially dependent upon the precise spatial arrangement of proteins in the pre- and postsynaptic apparatus. PDZ domain-containing proteins suc...
TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area
TRPC4 ion channel protein subpopulation of dopamine neurons ventral tegmental area Neurons and Cognition
2012/4/28
The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their ...