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选择性多聚腺苷酸化 (Alternative polyadenylation，APA) 是真核生物中普遍存在的一种转录调控机制，能调控基因互作和表达且广泛参与肿瘤发展1。研究团队已有研究揭示相比肿瘤样本，体外培养的癌细胞系整体基因的3’UTR缩短，并揭示了APA 的变化可以影响细胞对多种抗癌药物的敏感性，与癌症病人临床分期和预后等高度相关2。相关研究也揭示APA 参与调节各种免疫细胞的免疫反应，以...
2022 Cell Research Symposium: Cancer and Immunity: Mechanism and Therapeutics First announcement(September 21-23, 2022,Tiantai)（图）
Cell Research Symposium Cancer Immunity Tiantai 细胞研究学术研讨会 癌症 免疫
2023/2/19
Cell Research (CR) is hosting a symposium series on cancer and immunity , covering the latest, most exciting topics on cancer and immunity. Cell Research Symposia (CR Symposia) aims to promote and fac...
Scientists 'farm' natural killer cells in novel cancer-fighting approach（图）
Scientists farm natural killer cells novel cancer-fighting approach
2021/3/5
Building on the promise of emerging therapies to deploy the body's "natural killer" immune cells to fight cancer, researchers at the University of Michigan have gone one step farther.They've...
New technology tracks role of macrophages in cancer spread（图）
New technology tracks role macrophages cancer spread
2020/11/6
Macrophages, cells that help engulf and destroy harmful organisms in the body, tend to be characterized as the Jekyll and Hydes of the immune system.Macrophages are essential first responders in fight...
树突状细胞（DC）疫苗是目前在临床上应用的一种肿瘤治疗疫苗，其制备过程一般都在病人体外进行，病人来源的DC在体外进行诱导分化后再回输给病人，这种疫苗制备过程十分复杂，容易被污染，不同的技术人员、不同条件的实验室制备的疫苗疗效差异较大，较难标准化，因此体外制备的DC疫苗很难在临床推广应用。
2020年4月16日，Journal for ImmunoTherapy of Cancer (JITC)杂志在线发表了上海交通大学医学院上海市免疫学研究所李斌课题组和复旦大学附属妇产科医院乳腺外科吴克瑾课题组合作的成果“Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast canc...
Tiny tech reprograms immune cells to fight cancer
Tiny tech reprograms immune cells fight cancer
2017/4/27
Dr. Matthias Stephan has a bold vision. He imagines a future where patients with leukemia could be treated as early as the day they are diagnosed with cellular immunotherapy that’s available in their ...
HOUSTON — (Oct. 31, 2014) — In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The...
“Recent research has found that cancer is already adept at using cyberwarfare against the immune system, and we studied the interplay between cancer and the immune system to see how we might turn the ...