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The effects of dietary protein intake on appendicular lean mass and muscle function in elderly men: a 10-wk randomized controlled trial
nutrient requirements dietary protein skeletal muscle older adults whole foods
2018/11/21
Background: The Recommended Daily Allowance (RDA) for protein intake in the adult population is widely promoted as 0.8 g · kg−1 · d−1. Aging may increase protein requirements, particularly...
Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis
elderly people obesity protein supplementation resistance exercise body composition
2018/11/16
Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a benef...
Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis
elderly people obesity protein supplementation resistance exercise body composition
2018/11/20
Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a benef...
2017冷泉港亚洲会议： 膜蛋白：结构与功能（Cold Spring Harbor Asia conference on Membrane Proteins: Structure & Function）
Membrane Proteins Structure Function
2017/1/19
We are pleased to announce the Cold Spring Harbor Asia conference on Membrane Proteins: Structure & Function which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The c...
Progress in standardizing and harmonizing thyroid function tests
clinical laboratory tests harmonization international iodine standardization
2018/12/14
Iodine is an essential component of thyroid hormone. Because thyroid hormone synthesis is affected by iodine deficiency on the one hand and by excess iodine intake on the other, thyroid function bioma...
Architecture and Function of Membrane Proteins in Planar Supported Bilayers:A Study with Photosynthetic Reaction Centers
Arabidopsis plant DNA repair photoreactivation plant blue-light receptor AT-PHH1
2016/5/23
We present a simple and convenient method for creating fluid supported bilayers which contain oriented and functional photosynthetic reaction centers (RCs). The supported bilayers are prepared by fusi...
Modulation of Protein Function by Exogenous Ligands in Protein Cavities:CO Binding to a Myoglobin Cavity Mutant Containing Unnatural Proximal Ligands
Animals Binding Sites Carbon Monoxide Cloning, Molecular Escherichia coli Heme Kinetics Ligands Magnetic Resonance Spectroscopy Mutagenesis, Site-Directed Myoglobin Myoglobin Point Mutation Protein Conformation ecombinant Proteins Recombinant Proteins Spectroscopy,Fourier Transform Infrared Valine Whales
2016/5/23
A variety of heterocyclic ligands can be exchanged into the proximal cavity of sperm whale myoglobin mutant H93G, providing a simple method for introduction of the equivalent of unnatural amino acid s...
Mg Coordination by Amino Acid Side Chains is Not Required for Assembly and Function of the Special Pair in Bacterial Photosynthetic Reaction Centers
Amino Acids Fourier Analysis Light-Harvesting Protein Complexes Magnesium xidation-Reduction Photosynthetic Reaction Center Complex Proteins Spectrometry,Fluorescence Spectrum Analysis, Raman
2016/5/23
A conserved histidine serves as the axial ligand to the Mg of bacteriochlorophylls in the photosynthetic reaction center (RC) and many other photosynthetic systems. The histidine axial ligands to each...
Dietary plant stanol ester consumption improves immune function in asthma patients: results of a randomized, double-blind clinical trial
asthma IgE immune function plant stanol esters vaccination response
2018/11/27
Background: In vitro and ex vivo studies have suggested that plant sterols and stanols can shift the T helper (Th) 1/Th2 balance toward a Th1-type immune response, which may be beneficial in Th2-domin...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
The stability of T7 RNA polymerase elongation complexes and promoter function analysis by in vitro selection
Forward translocation model polymerase complex stability DNA structure
2014/12/11
The forward translocation model (paused or stalled polymerase moves forward in the absence of transcription, dissociation of the complex happens when hybrid is too short to stabilize the complex) is t...
The influence of WC1 isoforms on gammadelta T cell function
Scavenger receptor WC1 molecules diversity rich cysteine membrane surface glycoprotein T cells
2014/12/11
WC1 molecules are an extensively diversified family of integral type 1 scavenger receptor cysteine rich (SRCR) membrane glycoproteins expressed on the surface of arteriodactyls such as sheep, cattle, ...
New Insights in the TSSK Family: Studies in the Activity and Function of the Testis Specific Serine Kinases
Capza3 Gamete Fusion Izumo Kinase Mouse sperm Tssk
2014/12/10
The Testis Specific Serine Kinase (Tssk) family of proteins is a large group of kinases that present high level of conservation within paralogs, as well as within species. In addition, in all reported...
An Integrative Approach Towards Understanding The Structure- Function Relationship Of The Epigenetic Regulator Methyl Cpg Binding Protein 2
Pure sciences Biological sciences Epigenetic regulator Methyl CpG Binding protein 2 Binding dynamics of caps Chromatin architectural proteins (caps) Intrinsically disordered protein Nucleosome Protein folding
2014/12/10
Methyl CpG binding protein 2 (MeCP2) is a methylated DNA binding protein which, when mutated, leads to a severe neurodevelopmental disorder known as Rett syndrome (RTT). In the present work I have sho...
Structure, Function, and Pharmacological Chaperones for Human α-N-Acetylgalactosaminidase
Pure sciences Biological sciences Galactosidase Acetylgalactosaminidase Lysosomal storage disease Pharmacological chaperones Structural biology X-ray crystallography
2014/12/10
Human lysosomal α-N-acetylgalactosaminidase (α-NAGAL) is responsible for the break down of glycolipids and glycopeptides that contain a terminal α-linked N-acetylgalactosamine residues. Deficiency of ...